二苯基二硒醚减轻溃疡性结肠炎中的氧化应激和炎症参数：与依布硒啉的比较。
Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen.
作者信息
Petronilho Fabricia, Michels Monique, Danielski Lucinéia G, Goldim Mariana Pereira, Florentino Drielly, Vieira Andriele, Mendonça Mariana G, Tournier Moema, Piacentini Bárbara, Giustina Amanda Della, Leffa Daniela D, Pereira Gregório W, Pereira Volnei D, Rocha João Batista Teixeira Da
机构信息
Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
出版信息
Pathol Res Pract. 2016 Sep;212(9):755-60. doi: 10.1016/j.prp.2016.04.012. Epub 2016 May 2.
OBJETIVE
The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)2 and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats.
METHODS
The effects of (PhSe)2 and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations.
RESULTS
Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)2 improved this response. Moreover, the treatment with (PhSe)2 decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model.
CONCLUSIONS
The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)2 more effective than EB.
目的
本研究旨在评估二苯基二硒醚（PhSe）2和依布硒啉（EB）对葡聚糖硫酸钠（DSS）诱导的大鼠溃疡性结肠炎（UC）的影响。
方法
通过测量氧化应激参数、炎症反应和肠道组织病理学改变，确定（PhSe）2和EB对DSS诱导的大鼠结肠炎的影响。
结果
在组织病理学检测中，DSS大鼠出现中度至重度中性粒细胞浸润，（PhSe）2改善了这种反应。此外，（PhSe）2治疗降低了脂质和蛋白质的氧化损伤，并逆转了DSS处理大鼠的超氧化物歧化酶（SOD）和过氧化氢酶（CAT）水平。在该动物模型中，EB仅能逆转脂质损伤和SOD的低水平。
结论
所测试的有机硒化合物具有抗炎和抗氧化活性，可减少结肠损伤，（PhSe）2比EB更有效。
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