Moya Amanda Maria Tomazini Munhoz, Alexandrino Thaís Dolfini, Morari Joseane, Reguengo Livia Mateus, Velloso Licio Augusto, Leal Raquel Franco, Junior Stanislau Bogusz, Pereira Ana Paula Aparecida, Pastore Glaucia Maria, Bicas Juliano Lemos, Cazarin Cinthia Baú Betim
School of Food Engineering, Universidade Estadual de Campinas, Rua Monteiro Lobato, 80, Campinas 13083-862, São Paulo, Brazil.
School of Medical Sciences, Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo, 126, Campinas 13083-887, São Paulo, Brazil.
Foods. 2024 Sep 18;13(18):2949. doi: 10.3390/foods13182949.
St. Hil. is considered a natural anti-inflammatory. In traditional medicine, it is used to reduce cholesterol levels in the treatment of obesity. Foods capable of conferring a protective and nutritious effect have been used to prevent or attenuate the clinical symptoms of inflammatory bowel diseases. Ulcerative colitis is a multifactorial inflammatory bowel disease. This study investigated the impact of the consumption of the fibrous fraction (FF) and resistant starch (RS) of fruta-do-lobo in an experimental model of colitis induced with the use 2,4,6-trinitrobenzene sulphonic acid (TNBS) in rats. The different colitis groups all experienced decreased weight gain, which could be linked to the inflammatory process ( = 0.603). Additionally, the experimental model led to increased oxidative stress, higher levels of pro-inflammatory cytokines, and the elevated gene expression of these cytokines. Despite this, consuming the fibrous fraction of fruta-do-lobo (RS and FF) did not appear to protect the animals against the inflammatory process. Regarding the expression of TNF-α, only the group treated with the drug mesalamine had a reduced serum level of this inflammatory marker ( = 0.03). Our results showed that the diet containing RS and FF did not protect the intestinal mucosa against TNBS inflammation. New studies on the variation in the time of consumption or the supplemented dose of fruta-do-lobo fibers could help to elucidate their effects in protecting the mucosa.
圣希尔（St. Hil.）被认为是一种天然抗炎剂。在传统医学中，它被用于在肥胖症治疗中降低胆固醇水平。具有保护和营养作用的食物已被用于预防或减轻炎症性肠病的临床症状。溃疡性结肠炎是一种多因素炎症性肠病。本研究在大鼠中使用2,4,6-三硝基苯磺酸（TNBS）诱导的结肠炎实验模型中，研究了食用狼果的纤维部分（FF）和抗性淀粉（RS）的影响。不同的结肠炎组体重增加均减少，这可能与炎症过程有关（P = 0.603）。此外，实验模型导致氧化应激增加、促炎细胞因子水平升高以及这些细胞因子的基因表达升高。尽管如此，食用狼果的纤维部分（RS和FF）似乎并未保护动物免受炎症过程的影响。关于肿瘤坏死因子-α（TNF-α）的表达，只有用美沙拉嗪药物治疗的组该炎症标志物的血清水平降低（P = 0.03）。我们的结果表明，含有RS和FF的饮食并未保护肠黏膜免受TNBS炎症的影响。关于食用时间变化或狼果纤维补充剂量的新研究可能有助于阐明它们在保护黏膜方面的作用。
