Lanting Sean M, Johnson Nathan A, Baker Michael K, Caterson Ian D, Chuter Vivienne H
School of Health Sciences, University of Newcastle, Australia.
Faculty of Health Sciences, University of Sydney, Australia; Charles Perkins Centre, University of Sydney, Australia.
J Sci Med Sport. 2017 Feb;20(2):170-177. doi: 10.1016/j.jsams.2016.04.002. Epub 2016 Jun 1.
This study aimed to review the efficacy of exercise training for improving cutaneous microvascular reactivity in response to local stimulus in human adults.
Systematic review with meta-analysis.
A systematic search of Medline, Cinahl, AMED, Web of Science, Scopus, and Embase was conducted up to June 2015. Included studies were controlled trials assessing the effect of an exercise training intervention on cutaneous microvascular reactivity as instigated by local stimulus such as local heating, iontophoresis and post-occlusive reactive hyperaemia. Studies where the control was only measured at baseline or which included participants with vasospastic disorders were excluded. Two authors independently reviewed and selected relevant controlled trials and extracted data. Quality was assessed using the Downs and Black checklist.
Seven trials were included, with six showing a benefit of exercise training but only two reaching statistical significance with effect size ranging from -0.14 to 1.03. The meta-analysis revealed that aerobic exercise had a moderate statistically significant effect on improving cutaneous microvascular reactivity (effect size (ES)=0.43, 95% CI: 0.08-0.78, p=0.015).
Individual studies employing an exercise training intervention have tended to have small sample sizes and hence lacked sufficient power to detect clinically meaningful benefits to cutaneous microvascular reactivity. Pooled analysis revealed a clear benefit of exercise training on improving cutaneous microvascular reactivity in older and previously inactive adult cohorts. Exercise training may provide a cost-effective option for improving cutaneous microvascular reactivity in adults and may be of benefit to those with cardiovascular disease and metabolic disorders such as diabetes.
本研究旨在回顾运动训练对改善成年人体内局部刺激引起的皮肤微血管反应性的疗效。
系统评价与荟萃分析。
截至2015年6月，对Medline、Cinahl、AMED、Web of Science、Scopus和Embase进行了系统检索。纳入的研究为对照试验，评估运动训练干预对局部加热、离子电渗疗法和闭塞后反应性充血等局部刺激引发的皮肤微血管反应性的影响。排除仅在基线时测量对照或纳入血管痉挛性疾病参与者的研究。两位作者独立审查并选择相关对照试验并提取数据。使用唐斯和布莱克清单评估质量。
纳入七项试验，六项显示运动训练有益，但只有两项达到统计学显著性，效应大小在-0.14至1.03之间。荟萃分析显示，有氧运动对改善皮肤微血管反应性具有中度统计学显著效果（效应大小（ES）=0.43，95%CI：0.08-0.78，p=0.015）。
采用运动训练干预的个别研究往往样本量较小，因此缺乏足够的效力来检测对皮肤微血管反应性具有临床意义的益处。汇总分析显示，运动训练对改善老年和以前不活动的成年人群的皮肤微血管反应性有明显益处。运动训练可能为改善成年人的皮肤微血管反应性提供一种具有成本效益的选择，并且可能对患有心血管疾病和糖尿病等代谢紊乱的人有益。
