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p60v-src的肉豆蔻酰化信号在功能上补充了P130gag-fps的N端fps特异性区域。

The myristylation signal of p60v-src functionally complements the N-terminal fps-specific region of P130gag-fps.

作者信息

Brooks-Wilson A R, Ball E, Pawson T

机构信息

Division of Molecular and Developmental Biology, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada.

出版信息

Mol Cell Biol. 1989 May;9(5):2214-9. doi: 10.1128/mcb.9.5.2214-2219.1989.

DOI:10.1128/mcb.9.5.2214-2219.1989
PMID:2747647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC363016/
Abstract

The P130gag-fps protein-tyrosine kinase of Fujinami sarcoma virus contains an N-terminal fps-specific domain (Nfps) that is important for oncogenicity. The N-terminal 14 amino acids of p60v-src, which direct myristylation and membrane association, can replace the gag-Nfps sequences of P130gag-fps (residues 1 to 635), producing a highly transforming src-fps polypeptide. Conversely, gag-Nfps can restore modest transforming activity to a nonmyristylated v-src polypeptide. These results emphasize the modular construction of protein-tyrosine kinases and indicate that Nfps, possibly in conjunction with gag, functions in the subcellular localization of P130gag-fps.

摘要

藤浪肉瘤病毒的P130gag-fps蛋白酪氨酸激酶含有一个对致癌性很重要的N端fps特异性结构域（Nfps）。p60v-src的N端14个氨基酸可指导肉豆蔻酰化和膜结合，它能取代P130gag-fps的gag-Nfps序列（第1至635位氨基酸），产生一种具有高度转化能力的src-fps多肽。相反，gag-Nfps可恢复非肉豆蔻酰化v-src多肽的适度转化活性。这些结果强调了蛋白酪氨酸激酶的模块化结构，并表明Nfps可能与gag协同作用，在P130gag-fps的亚细胞定位中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db9a/363016/ef99c1ff1bc3/molcellb00053-0415-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db9a/363016/b14b8b7567d3/molcellb00053-0414-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db9a/363016/f313eff29ee1/molcellb00053-0414-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db9a/363016/49c17a6f5b28/molcellb00053-0415-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db9a/363016/ef99c1ff1bc3/molcellb00053-0415-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db9a/363016/b14b8b7567d3/molcellb00053-0414-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db9a/363016/f313eff29ee1/molcellb00053-0414-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db9a/363016/49c17a6f5b28/molcellb00053-0415-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db9a/363016/ef99c1ff1bc3/molcellb00053-0415-b.jpg

相似文献

1
The myristylation signal of p60v-src functionally complements the N-terminal fps-specific region of P130gag-fps.p60v-src的肉豆蔻酰化信号在功能上补充了P130gag-fps的N端fps特异性区域。
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本文引用的文献

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Normal rat cell lines deficient in nuclear thymidine kinase.缺乏细胞核胸苷激酶的正常大鼠细胞系。
Virology. 1981 Aug;113(1):408-11. doi: 10.1016/0042-6822(81)90168-9.
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Detergent binding to unmyristylated protein kinase A--structural implications for the role of myristate.去污剂与未豆蔻酰化的蛋白激酶A的结合——豆蔻酸盐作用的结构意义
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The ADP/ATP carrier is the 32-kilodalton receptor for an NH2-terminally myristylated src peptide but not for pp60src polypeptide.ADP/ATP载体是一种32千道尔顿的受体，可与氨基末端肉豆蔻酰化的src肽结合，但不能与pp60src多肽结合。
Mol Cell Biol. 1993 May;13(5):3084-92. doi: 10.1128/mcb.13.5.3084-3092.1993.
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The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family.FER基因在进化上是保守的，编码FPS/FES蛋白酪氨酸激酶家族中广泛表达的一个成员。
Mol Cell Biol. 1989 Dec;9(12):5722-5. doi: 10.1128/mcb.9.12.5722-5725.1989.
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Delineation of functional determinants in the transforming protein of Fujinami sarcoma virus.藤浪肉瘤病毒转化蛋白中功能决定因素的描绘
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9
A myristylated form of the sea oncoprotein can transform chicken embryo fibroblasts.海生癌蛋白的一种豆蔻酰化形式可转化鸡胚成纤维细胞。
J Virol. 1991 May;65(5):2533-8. doi: 10.1128/JVI.65.5.2533-2538.1991.
10
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.蛋白质酪氨酸激酶调节p21ras GTP酶激活蛋白的磷酸化、蛋白质相互作用、亚细胞分布及活性。
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Cell. 1984 Jun;37(2):549-58. doi: 10.1016/0092-8674(84)90385-4.
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Monoclonal antibodies to the transforming protein of Fujinami avian sarcoma virus discriminate between different fps-encoded proteins.针对藤浪氏禽肉瘤病毒转化蛋白的单克隆抗体可区分不同的fps编码蛋白。
J Virol. 1984 May;50(2):572-8. doi: 10.1128/JVI.50.2.572-578.1984.
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Nucleotide sequence of v-fps in the PRCII strain of avian sarcoma virus.禽肉瘤病毒PRCII株中v-fps的核苷酸序列。
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Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses.识别禽肉瘤病毒转化蛋白的单克隆抗体的分离
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Immunofluorescent localization of the transforming protein of Rous sarcoma virus with antibodies against a synthetic src peptide.用针对合成src肽的抗体对劳氏肉瘤病毒转化蛋白进行免疫荧光定位。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5322-6. doi: 10.1073/pnas.79.17.5322.