Hara T, Makita T, Horiya N, Ozawa S, Ohba M, Naito J, Shibuya T
Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan.
Mutat Res. 1989 Aug;223(4):349-52. doi: 10.1016/0165-1218(89)90083-9.
The effect of route of administration on the induction of micronucleated polychromatic erythrocytes (MNPCEs) was examined. 6-Mercaptopurine monohydrate (6-MP) was administered intraperitoneally (i.p.) or orally (p.o.) to 2 strains of mice, MS/Ae and CD-1. From the results of an acute toxicity test and a pilot micronucleus test, the doses selected for the final micronucleus test were 12.5-100 mg/kg for the i.p. route and 25-200 mg/kg for the p.o. route. The sampling time was 48 h. Frequencies of MNPCEs increased dose-dependently by the i.p. route but peaked at 50 or 100 mg/kg for the p.o. route. 6-MP induced MNPCEs more efficiently after p.o. administration than after i.p. treatment in both strains.
研究了给药途径对诱导微核多染性红细胞（MNPCEs）的影响。将一水合6-巯基嘌呤（6-MP）经腹腔注射（i.p.）或口服（p.o.）给予2个品系的小鼠，即MS/Ae和CD-1。根据急性毒性试验和预试验微核试验的结果，最终微核试验选择的剂量为腹腔注射途径12.5 - 100 mg/kg，口服途径25 - 200 mg/kg。取样时间为48小时。微核多染性红细胞的频率经腹腔注射途径呈剂量依赖性增加，但经口服途径在50或100 mg/kg时达到峰值。在两个品系中，6-MP口服给药后诱导微核多染性红细胞的效率均高于腹腔注射给药后。
