Inouye T, Imanishi H, Watanabe M, Sasaki Y F, Shirasu Y, Ando N, Ishii S
Institute of Environmental Toxicology, Tokyo, Japan.
Mutat Res. 1989 Aug;223(4):411-4. doi: 10.1016/0165-1218(89)90098-0.
The difference in effect of route of administration of procarbazine hydrochloride (PCZ) in the mouse was investigated in the micronucleus test. PCZ was administered by intraperitoneal injection (i.p.) and oral administration (p.o.) to 2 strains of male mice (MS/Ae and CD-1). On the basis of a small-scale acute toxicity test and a pilot micronucleus test, bone marrow preparations were prepared 24 h after the administration by the i.p. and p.o. routes of 50-400 mg/kg and 200-1600 mg/kg, respectively. The maximum incidence of polychromatic erythrocytes with micronuclei (MNPCEs) was somewhat higher after p.o. treatment in MS/Ae mice and the same with both routes in CD-1 mice. Thus, the clastogenicity of PCZ in mouse bone marrow was revealed by both routes.
在微核试验中研究了盐酸丙卡巴肼（PCZ）给药途径对小鼠的影响差异。将PCZ通过腹腔注射（i.p.）和口服（p.o.）给予2个品系的雄性小鼠（MS/Ae和CD-1）。根据小规模急性毒性试验和预试验微核试验，分别以50-400mg/kg和200-1600mg/kg的剂量通过腹腔注射和口服途径给药后24小时制备骨髓制剂。在MS/Ae小鼠中，口服给药后多染性红细胞微核（MNPCEs）的最大发生率略高，而在CD-1小鼠中两种途径相同。因此，两种给药途径均显示了PCZ对小鼠骨髓的致断裂性。
