阿扑吗啡和咖啡因诱导的旋转行为与黑质纹状体通路单侧损伤大鼠之间的关系。
Relationship between rotational behaviour induced by apomorphine and caffeine in rats with unilateral lesion of the nigrostriatal pathway.
作者信息
Casas M, Ferré S, Cobos A, Grau J M, Jané F
机构信息
Laboratori de Neuropsicofarmacología i Programa Sant Pau-CITRAN, Fundació d'Investigació de la Santa Creu i Sant Pau, Hospital de Sant Pau (Medical School, U.A.B.), Barcelona, Spain.
出版信息
Neuropharmacology. 1989 Apr;28(4):407-9. doi: 10.1016/0028-3908(89)90037-3.
The contralateral rotational behaviour produced by apomorphine and caffeine has been studied in 100 rats with unilateral lesion of the nigrostriatal pathway induced with 6-OHDA. Rats with a two-peak rotational pattern induced by apomorphine, showed a greater number of contralateral turns, induced by apomorphine and caffeine, than rats which did not show this rotational pattern. A correlation was observed between the number of rotations induced by apomorphine and those induced by caffeine. A relationship between the two-peak rotational pattern induced by apomorphine and the initial-peak pattern induced by caffeine was also observed.
已对100只经6-羟基多巴胺诱导造成黑质纹状体通路单侧损伤的大鼠，研究了阿扑吗啡和咖啡因所产生的对侧旋转行为。与未表现出这种旋转模式的大鼠相比，阿扑吗啡诱导出双峰旋转模式的大鼠，由阿扑吗啡和咖啡因诱导出的对侧旋转次数更多。观察到阿扑吗啡诱导的旋转次数与咖啡因诱导的旋转次数之间存在相关性。还观察到阿扑吗啡诱导的双峰旋转模式与咖啡因诱导的初始峰值模式之间的关系。
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