Becherucci Francesca, Roperto Rosa Maria, Materassi Marco, Romagnani Paola
Nephrology and Dialysis Unit , Meyer Children's Hospital , Florence , Italy.
Nephrology andDialysis Unit, Meyer Children's Hospital, Florence, Italy; Department ofBiomedical Experimental and Clinical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Clin Kidney J. 2016 Aug;9(4):583-91. doi: 10.1093/ckj/sfw047. Epub 2016 Jun 5.
Chronic kidney disease (CKD) is a major health problem worldwide. Although relatively uncommon in children, it can be a devastating illness with many long-term consequences. CKD presents unique features in childhood and may be considered, at least in part, as a stand-alone nosologic entity. Moreover, some typical features of paediatric CKD, such as the disease aetiology or cardiovascular complications, will not only influence the child's health, but also have long-term impact on the life of the adult that they will become. In this review we will focus on the unique issues of paediatric CKD, in terms of aetiology, clinical features and treatment. In addition, we will discuss factors related to CKD that start during childhood and require appropriate treatments in order to optimize health outcomes and transition to nephrologist management in adult life.
慢性肾脏病（CKD）是全球范围内的一个主要健康问题。尽管在儿童中相对不常见，但它可能是一种具有许多长期后果的毁灭性疾病。CKD在儿童期呈现出独特的特征，并且至少在一定程度上可被视为一个独立的病种。此外，儿童CKD的一些典型特征，如疾病病因或心血管并发症，不仅会影响儿童的健康，还会对他们成年后的生活产生长期影响。在本综述中，我们将重点关注儿童CKD在病因、临床特征和治疗方面的独特问题。此外，我们还将讨论与儿童期起病的CKD相关的因素，这些因素需要适当的治疗，以优化健康结局并顺利过渡到成年后的肾病专科管理。
