Christian S S, Duff P
Division of Maternal-Fetal Medicine, Madigan Army Medical Center, Tacoma, Washington.
Obstet Gynecol. 1989 Aug;74(2):259-61.
The purpose of this prospective study was to determine the prevalence of asymptomatic hepatitis B infection in a low-risk, closely monitored population. At the time of their first prenatal evaluation, a cohort of active-duty military personnel and their dependents underwent screening for hepatitis B surface antigen. Ten of 1520 women (0.66%) tested positive. All of these women were Asians and would have been identified under a selective screening protocol. None of the ten seropositive patients had other risk factors for hepatitis B infection. We conclude that in this type of population, universal screening for hepatitis B is not cost-effective. Selective screening for high-risk patients would appear to be more appropriate.
这项前瞻性研究的目的是确定在一个低风险、密切监测的人群中无症状乙肝感染的患病率。在首次产前评估时，一组现役军人及其家属接受了乙肝表面抗原筛查。1520名女性中有10名（0.66%）检测呈阳性。所有这些女性均为亚洲人，在选择性筛查方案下本可被识别出来。这10名血清反应阳性患者均无其他乙肝感染风险因素。我们得出结论，在这类人群中，普遍进行乙肝筛查不具有成本效益。对高危患者进行选择性筛查似乎更为合适。
