Davidson R J, Walker W, Watt J L, Page B M
Scand J Haematol. 1978 Apr;20(4):351-9. doi: 10.1111/j.1600-0609.1978.tb02467.x.
Clinical and haematological details of 2 siblings with a familial myeloproliferative disorder (erythroleukaemia) are presented. Their father is presumed to have died from a similar disease. The 2 siblings showed similar but not identical chromosomal abnormalities detected initially in marrow and later in peripheral blood. Serial studies revealed the emergence of an increasingly diverse pattern of chromosomal changes coincident with the haematological and clinical progression of the disease. Other members of the family were screened for cytogenetic and haematological changes. The paternal sibship displayed an increased incidence of cancer.
本文介绍了2名患有家族性骨髓增殖性疾病（红白血病）的兄弟姐妹的临床和血液学细节。据推测，他们的父亲死于类似疾病。这2名兄弟姐妹最初在骨髓中，后来在外周血中检测到相似但不完全相同的染色体异常。系列研究显示，随着疾病的血液学和临床进展，出现了越来越多样化的染色体变化模式。对该家族的其他成员进行了细胞遗传学和血液学变化筛查。父系亲属患癌症的发生率有所增加。
