Li Y S, Khalid G, Matthews J G, Hayhoe F G
Leuk Res. 1983;7(6):755-9. doi: 10.1016/0145-2126(83)90069-3.
A case of erythroleukaemia with homogeneously staining regions on chromosomes is described. The number of chromosomes in bone marrow cells varied from 41 to 46 with a mode of 43. A variety of structural and numerical chromosomal abnormalities was observed. Two marker chromosomes with homogeneously staining regions were found in all aneuploid cells examined. Intensive chemotherapy failed to induce a remission and the patient died 3.9 months after diagnosis. The relation of the homogeneously staining regions on chromosomes to the two courses of chemotherapy prior to cytogenetic study is discussed.
本文描述了一例染色体上存在均匀染色区的红白血病病例。骨髓细胞的染色体数目在41至46条之间变化，众数为43条。观察到多种结构和数目染色体异常。在所有检测的非整倍体细胞中均发现两条带有均匀染色区的标记染色体。强化化疗未能诱导缓解，患者在诊断后3.9个月死亡。本文还讨论了染色体上均匀染色区与细胞遗传学研究之前两个化疗疗程的关系。
