Finitsis David J, Pellowski Jennifer A, Huedo-Medina Tania B, Fox Matthew C, Kalichman Seth C
Center for Health, Intervention, and Prevention, Department of Psychology, University of Connecticut, Storrs, CT, USA.
J Behav Med. 2016 Dec;39(6):1043-1055. doi: 10.1007/s10865-016-9770-6. Epub 2016 Aug 1.
Effective treatment of HIV hinges upon maintaining adequate antiretroviral therapy adherence. Accurate, cost-effective measurement of medication adherence is needed to best respond to the HIV pandemic. The visual analogue scale (VAS) appears to be a simple and easy to use measure of adherence but the current literature on its use is mixed. This meta-analysis (1) describes VAS concordance with other measures of medication adherence and viral load; and (2) examines how research methods moderate the reported strength of the VAS-viral load relationship. Literature searches were conducted electronically and by hand with a total of 20 studies included in the present study. The VAS showed large strength associations with most other measures of adherence and a smaller association with viral load. More rigorous methodological quality significantly improved the VAS-viral load effect size. We conclude with optimization recommendations for VAS use in clinical practice and research design.
有效治疗艾滋病毒取决于维持足够的抗逆转录病毒疗法依从性。为了更好地应对艾滋病毒大流行，需要准确且具成本效益的药物依从性测量方法。视觉模拟量表（VAS）似乎是一种简单易用的依从性测量方法，但目前关于其使用的文献结果不一。本荟萃分析：（1）描述VAS与其他药物依从性和病毒载量测量方法的一致性；（2）研究研究方法如何调节所报告的VAS与病毒载量关系的强度。通过电子和手工方式进行文献检索，本研究共纳入20项研究。VAS与大多数其他依从性测量方法显示出很强的关联，与病毒载量的关联较小。更严格的方法学质量显著改善了VAS与病毒载量的效应大小。我们最后针对VAS在临床实践和研究设计中的使用提出了优化建议。
