Kwon Chang-Il, Kim Hong Joo, Korc Paul, Choi Eun Kwang, McNulty Gail M, Easler Jeffrey J, El Hajj Ihab I, Watkins James, Fogel Evan L, McHenry Lee, Zimmerman Michelle K, Sherman Stuart, Lehman Glen A
From the *Division of Gastroenterology/Hepatology, and †Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.
Pancreas. 2016 Sep;45(8):1184-8. doi: 10.1097/MPA.0000000000000612.
The aims of this study were to evaluate whether serum pancreatic enzyme levels could be used to aid screening for chronic pancreatitis (CP).
170 healthy volunteers were screened and prospectively enrolled in the control group. 150 patients who were diagnosed with calcific CP were enrolled in the patient group by retrospective review. Serum amylase and lipase levels were compared between the 2 groups.
The mean values ± SD of the control group were compared with those of the patient group for serum amylase level (48.1 ± 13.2 vs 34.8 ± 17.2 U/L, P < 0.001) and serum lipase level (26.4 ± 11.3 vs 16.3 ± 11.2 U/L, P < 0.001). On the receiver operating characteristic curve analysis for amylase level, area under the curve was 0.740 (95% confidence interval), and sensitivity and specificity were 38.7% and 94.1%, respectively, with a cutoff value of 27.5 U/L. On the receiver operating characteristic curve analysis for lipase level, area under the curve was 0.748 (95% confidence interval), and sensitivity and specificity were 33.3% and 95.9%, respectively, with a cutoff value of 10.5 U/L.
Our results suggest that low serum pancreatic enzyme levels can be used to aid in detection of CP.
本研究旨在评估血清胰酶水平是否可用于辅助慢性胰腺炎（CP）的筛查。
对170名健康志愿者进行筛查，并前瞻性纳入对照组。通过回顾性分析，将150例诊断为钙化性CP的患者纳入患者组。比较两组的血清淀粉酶和脂肪酶水平。
比较对照组和患者组血清淀粉酶水平的均值±标准差（48.1±13.2 vs 34.8±17.2 U/L，P<0.001）以及血清脂肪酶水平的均值±标准差（26.4±11.3 vs 16.3±11.2 U/L，P<0.001）。在淀粉酶水平的受试者工作特征曲线分析中，曲线下面积为0.740（95%置信区间），灵敏度和特异度分别为38.7%和94.1%，截断值为27.5 U/L。在脂肪酶水平的受试者工作特征曲线分析中，曲线下面积为0.748（95%置信区间），灵敏度和特异度分别为33.3%和95.9%，截断值为10.5 U/L。
我们的结果表明，低血清胰酶水平可用于辅助CP的检测。
