Hussein T M, Elneily D, Eid A A, Abou-ElKhier H
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Andrologia. 2017 Jun;49(5). doi: 10.1111/and.12664. Epub 2016 Aug 3.
Association of hepatitis C virus (HCV) with autoimmune phenomena and impaired semen parameters has been previously reported. The aim of this study was to investigate the influence of HCV infection on the development of antisperm antibodies (ASAs) in HCV-positive males. The study was conducted on 30 HCV-infected individuals and 30 healthy control subjects. In both patients and control groups, liver enzymes and reproductive hormones were measured; computer-assisted semen analysis (CASA) was performed; HCV-RNA in serum was measured and IgG and IgA ASAs in semen were determined. Free testosterone, sperm concentration, progressive and total motility were significantly lower in HCV patients than in the control group, whereas ASAs of the IgG and IgA classes were significantly higher in HCV patients. However, correlations between viral load and the examined semen parameters and ASAs were nonsignificant. In conclusion, HCV may be responsible for the increased ASAs detected in HCV patients in the present study, possibly providing another plausible explanation for the decreased sperm motility reported in HCV patients. These findings could be of value in fertility management of HCV patients.
先前已有报道丙型肝炎病毒（HCV）与自身免疫现象及精液参数受损有关。本研究的目的是调查HCV感染对HCV阳性男性抗精子抗体（ASA）产生的影响。该研究对30名HCV感染者和30名健康对照者进行。在患者和对照组中，均检测了肝酶和生殖激素；进行了计算机辅助精液分析（CASA）；检测了血清中的HCV-RNA，并测定了精液中的IgG和IgA ASA。HCV患者的游离睾酮、精子浓度、前向运动和总活力显著低于对照组，而HCV患者的IgG和IgA类ASA显著更高。然而，病毒载量与所检测的精液参数及ASA之间的相关性不显著。总之，在本研究中HCV可能是导致HCV患者中检测到的ASA增加的原因，这可能为HCV患者精子活力下降提供另一种合理的解释。这些发现可能对HCV患者的生育管理具有价值。
