Karamolahi Sana, Yazdi Reza Salman, Zangeneh Mehrangiz, Makiani Mahin Jamshidi, Farhoodi Behnam, Gilani Mohammad Ali Sedighi
Tehran Medical Sciences, Branch Islamic Azad University Tehran Iran.
Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR Tehran Iran.
Int J Reprod Biomed. 2019 Sep 3;17(8):551-556. doi: 10.18502/ijrm.v17i8.4820. eCollection 2019 Aug.
Viral hepatitis is one of the health problems which have the effects on the health issues. It seems that hepatitis B virus (HBV) and hepatitis C virus (HCV) infection have negative impacts on the semen quality and male infertility rate.
In this study, we aimed to evaluate the effects of HBV and HCV on sperm quality among Iranian infertile men referred to Royan Institute Reproductive Biomedicine Research Center between 2003 and 2014.
This retrospective case-control study included 112 HBV positive infertile men and 47 HCV positive infertile men as case group and 112 HBV negative and HCV negative matched infertile men as a control group. All semen analysis and viral parameters assessment was performed in the central laboratory with the same method and instruments.
Sperm count among infertile men with HBV and HCV infection was significantly lower than control group [the mean of the total sperm count 100.95░±░118.59, 118.22░±░141.18, 166.27░±░151.25 (p░<░0.001)]. Sperm motility was significantly decreased in HBV and HCV positive men in comparison to the control group [30.97░±░25.88, 31.09░±░28.72, 40.87░±░23.37, respectively (p░<░0.007)]. The percentage of normal sperm morphology was significantly higher in control group in comparison to HBV and HCV infected group [the mean of the normal semen morphology 3.23░±░3.27, 3.70░±░3.83, 4.51░±░3.15 p░<░0.015]. Although there is a significant decline in liquefaction time in the case group but the viscosity, semen volume, and PH of semen samples were similar in the both case and control groups.
Our results suggest that HBV and HCV infection are associated with poor sperm quality.
病毒性肝炎是影响健康问题的健康问题之一。乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染似乎对精液质量和男性不育率有负面影响。
在本研究中，我们旨在评估2003年至2014年间转诊至罗扬生殖生物医学研究中心的伊朗不育男性中HBV和HCV对精子质量的影响。
这项回顾性病例对照研究包括112名HBV阳性不育男性和47名HCV阳性不育男性作为病例组，以及112名HBV阴性和HCV阴性的匹配不育男性作为对照组。所有精液分析和病毒参数评估均在中央实验室使用相同的方法和仪器进行。
HBV和HCV感染的不育男性的精子计数显著低于对照组[总精子计数的平均值分别为100.95±118.59、118.22±141.18、166.27±151.25（p<0.001）]。与对照组相比，HBV和HCV阳性男性的精子活力显著降低[分别为30.97±25.88、31.09±28.72、40.87±23.37（p<0.007）]。与HBV和HCV感染组相比，对照组正常精子形态的百分比显著更高[正常精液形态的平均值分别为3.23±3.27、3.70±3.83、4.51±3.15，p<0.015]。虽然病例组的液化时间有显著下降，但病例组和对照组的精液样本的粘度、精液体积和pH值相似。
我们的结果表明，HBV和HCV感染与精子质量差有关。
