Immunology, Department of Medicine, Verona University Hospital, Verona, Italy.
Medical Oncology, Department of Medicine, Verona University Hospital, Verona, Italy.
Cancer Discov. 2016 Aug;6(8):821-3. doi: 10.1158/2159-8290.CD-16-0682.
Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight. Cancer Discov; 6(8); 821-3. ©2016 AACR.See related article by Incio et al., p. 852.
肥胖引起的炎症会在胰腺腺癌中形成一个局限的微环境，与肿瘤基质增多、中性粒细胞募集、化疗药物递送减少和免疫逃逸有关。针对赋予该回路的分子途径可能是为超重患者的联合治疗达到临床疗效的必要措施。Cancer Discov; 6(8); 821-3. ©2016 AACR. 参见 Incio 等人的相关文章，第 852 页。
