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基于抗结核异烟肼锌铝层状双氢氧化物的纳米复合材料的合成、表征及疗效

Synthesis, characterization, and efficacy of antituberculosis isoniazid zinc aluminum-layered double hydroxide based nanocomposites.

作者信息

Saifullah Bullo, El Zowalaty Mohamed Ezzat, Arulselvan Palanisamy, Fakurazi Sharida, Webster Thomas J, Geilich Benjamin Mahler, Hussein Mohd Zobir

机构信息

Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, (ITMA), Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, South Africa; Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience.

出版信息

Int J Nanomedicine. 2016 Jul 15;11:3225-37. doi: 10.2147/IJN.S102406. eCollection 2016.

DOI:10.2147/IJN.S102406
PMID:27486322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4956062/
Abstract

The chemotherapy for tuberculosis (TB) is complicated by its long-term treatment, its frequent drug dosing, and the adverse effects of anti-TB drugs. In this study, we have developed two nanocomposites (A and B) by intercalating the anti-TB drug isoniazid (INH) into Zn/Al-layered double hydroxides. The average size of the nanocomposites was found to bê164 nm. The efficacy of the Zn/Al-layered double hydroxides intercalated INH against Mycobacterium tuberculosis was increased by approximately three times more than free INH. The nanocomposites were also found to be active against Gram-positive and -negative bacteria. Compared to the free INH, the nanodelivery formulation was determined to be three times more biocompatible with human normal lung fibroblast MRC-5 cells and 3T3 fibroblast cells at a very high concentration of 50 µg/mL for up to 72 hours. The in vitro release of INH from the Zn/Al-layered double hydroxides was found to be sustained in human body-simulated buffer solutions of pH 4.8 and 7.4. This research is a step forward in making the TB chemotherapy patient friendly.

摘要

结核病（TB）的化疗因治疗周期长、给药频繁以及抗结核药物的副作用而变得复杂。在本研究中，我们通过将抗结核药物异烟肼（INH）插层到Zn/Al层状双氢氧化物中，制备了两种纳米复合材料（A和B）。发现纳米复合材料的平均尺寸为164纳米。插层有INH的Zn/Al层状双氢氧化物对结核分枝杆菌的疗效比游离INH提高了约三倍。还发现纳米复合材料对革兰氏阳性和阴性细菌均有活性。与游离INH相比，在高达50μg/mL的非常高浓度下处理长达72小时时，纳米递送制剂与人正常肺成纤维细胞MRC-5细胞和3T3成纤维细胞的生物相容性被确定为游离INH的三倍。发现在pH 4.8和7.4的人体模拟缓冲溶液中，INH从Zn/Al层状双氢氧化物中的体外释放是持续的。这项研究朝着使结核病化疗对患者更友好迈出了一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/a2ce1b6fa940/ijn-11-3225Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/03cd5f126c59/ijn-11-3225Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/4e83454af155/ijn-11-3225Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/6175a62cbce1/ijn-11-3225Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/4ac12f7cb275/ijn-11-3225Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/dfd2a10e4d3e/ijn-11-3225Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/ab4e542cd506/ijn-11-3225Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/8d8a21dc2238/ijn-11-3225Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/fcecea21ee8a/ijn-11-3225Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/a2ce1b6fa940/ijn-11-3225Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/03cd5f126c59/ijn-11-3225Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/4e83454af155/ijn-11-3225Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/6175a62cbce1/ijn-11-3225Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/4ac12f7cb275/ijn-11-3225Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/dfd2a10e4d3e/ijn-11-3225Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/ab4e542cd506/ijn-11-3225Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/8d8a21dc2238/ijn-11-3225Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/fcecea21ee8a/ijn-11-3225Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b3/4956062/a2ce1b6fa940/ijn-11-3225Fig9.jpg

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