β-月桂烯对C57BL/J6小鼠全脑缺血/再灌注后的心脏保护作用。
The protective cardiac effects of Β-myrcene after global cerebral ıschemia/reperfusion in C57BL/J6 mouse.
作者信息
Burcu Gul Baykalir, Osman Ciftci, Aslı Cetin, Namik Oztanir Mustafa, Neşe Basak Türkmen
机构信息
Assistant Professor, Department of Pharmacology and Toxicology, Faculty of Veterinary, University of Firat, Elazig, Turkey. Acquisition of data, manuscript writing.
Professor, Department of Medical Pharmacology, Faculty of Medicine, University of Inonu, Malatya, Turkey. Design of the study, manuscript writing, carry out the study.
出版信息
Acta Cir Bras. 2016 Jul;31(7):456-62. doi: 10.1590/S0102-865020160070000005.
PURPOSE
To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice.
METHODS
Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR+IR. The control group was received 0.1% carboxymethyl cellulose as a vehicle following a medial incision without carotid occlusion. In the IR group, the bilateral carotid arteries were clipped for 15min, and treated with the vehicle intraperitoneally(ip) for 10 days. MYR (200mg/kg) was received dissolved in 0.1%CMC for 10 days. In the MYR+IR group, the IR model was applied exactly as in the IR group, and then they were treated with MYR 10 days.
RESULTS
The cerebral IR caused oxidative damage (increase TBARS, decrease antioxidant parameters). Treatment of MYR was increased in GSH,GPx,CAT,SOD activity while TBARS level was decreased. In addition, degenerative changes in I/R group heart tissue were ameliorated by MYR administration.
CONCLUSİON: The administration of β-myrcene protects oxidative and histological damage in the heart tissue after global ischemia-reperfusion and may be useful safe alternative treatment for cardiac tissue after ischemic stroke.
目的
研究β-月桂烯（MYR）对C57BL/J6小鼠全脑缺血/再灌注（IR）所致心脏组织氧化损伤和组织学损伤的保护作用。
方法
将40只动物随机分为四组：（1）对照组，（2）IR组，（3）MYR组和（4）MYR+IR组。对照组在进行无颈动脉闭塞的正中切口后，给予0.1%羧甲基纤维素作为赋形剂。IR组双侧颈动脉夹闭15分钟，并腹腔注射赋形剂10天。MYR组给予溶解于0.1%羧甲基纤维素中的MYR（200mg/kg），持续10天。在MYR+IR组，按照IR组的方法建立IR模型，然后给予MYR治疗10天。
结果
全脑IR导致氧化损伤（丙二醛增加，抗氧化参数降低）。MYR治疗可提高谷胱甘肽、谷胱甘肽过氧化物酶、过氧化氢酶、超氧化物歧化酶活性，同时降低丙二醛水平。此外，MYR给药可改善I/R组心脏组织的退行性变化。
结论
β-月桂烯给药可保护全脑缺血再灌注后心脏组织的氧化损伤和组织学损伤，可能是缺血性中风后心脏组织安全有效的替代治疗方法。
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