ASPIRE-VA行为性体重减轻干预试验中女性和男性的体重减轻情况。
Weight loss among women and men in the ASPIRE-VA behavioral weight loss intervention trial.
作者信息
Vimalananda Varsha, Damschroder Laura, Janney Carol A, Goodrich David, Kim H Myra, Holleman Robert, Gillon Leah, Lutes Lesley
机构信息
Center for Healthcare Organization and Implementation Research, Bedford VA Medical Center, Bedford, Massachusetts, USA.
Section of Endocrinology, Diabetes and Metabolism, Boston University School of Medicine, Boston, Massachusetts, USA.
出版信息
Obesity (Silver Spring). 2016 Sep;24(9):1884-91. doi: 10.1002/oby.21574. Epub 2016 Aug 4.
OBJECTIVE
Weight loss was examined among women and men veterans in a clinical trial comparing Aspiring for Lifelong Health (ASPIRE), a "small changes" weight loss program using either mixed-sex group-visit or telephone-based coaching, to MOVE!(®) , the usual mixed-sex group-based program.
METHODS
Linear mixed-effects models were used to calculate adjusted percent weight change at 12 months by sex and compare outcomes across arms within sex.
RESULTS
Analyses included 72 women (ASPIRE-Phone = 26; ASPIRE-Group = 26; MOVE! = 20) and 409 men (ASPIRE-Phone = 136; ASPIRE-Group = 134; MOVE! = 139). At 12 months, women displayed significant weight loss from baseline in ASPIRE-Group (-2.6%) and MOVE! (-2.7%), but not ASPIRE-Phone (+0.2%). Between-arm differences in weight change among women were: ASPIRE-Group versus ASPIRE-Phone, -2.8% (P = 0.15); MOVE! versus ASPIRE-Phone, -2.8% (P = 0.20); and ASPIRE-Group versus MOVE!, 0.0% (P = 1.0). At 12 months, men lost significant weight from baseline across arms (ASPIRE-Phone, -1.5%; ASPIRE-Group, -2.5%; MOVE!, -1.0%). Between-arm differences in weight change among men were: ASPIRE-Group versus ASPIRE-Phone, -0.9% (P = 0.23); MOVE! versus ASPIRE-Phone, +0.5% (P = 0.76); ASPIRE-Group versus MOVE!, -1.5% (P = 0.03).
CONCLUSIONS
Mixed-sex, group-based programs can result in weight loss for both women and men veterans.
目的
在一项临床试验中，对女性和男性退伍军人的体重减轻情况进行了研究。该试验将“追求终身健康”（ASPIRE）这一采用男女混合小组就诊或电话指导的“小改变”减肥计划，与常规的男女混合小组计划“行动！（MOVE!）”进行了比较。
方法
使用线性混合效应模型按性别计算12个月时的调整后体重变化百分比，并比较各性别组内不同方案的结果。
结果
分析纳入了72名女性（ASPIRE电话指导组 = 26人；ASPIRE小组就诊组 = 26人；行动！组 = 20人）和409名男性（ASPIRE电话指导组 = 136人；ASPIRE小组就诊组 = 134人；行动！组 = 139人）。在12个月时，ASPIRE小组就诊组（-2.6%）和行动！组（-2.7%）的女性体重相较于基线有显著减轻，但ASPIRE电话指导组（+0.2%）没有。女性体重变化的组间差异为：ASPIRE小组就诊组与ASPIRE电话指导组，-2.8%（P = 0.15）；行动！组与ASPIRE电话指导组，-2.8%（P = 0.20）；ASPIRE小组就诊组与行动！组，0.0%（P = 1.0）。在12个月时，各方案组的男性体重相较于基线均有显著减轻（ASPIRE电话指导组，-1.5%；ASPIRE小组就诊组，-2.5%；行动！组，-1.0%）。男性体重变化的组间差异为：ASPIRE小组就诊组与ASPIRE电话指导组，-0.9%（P = 0.23）；行动！组与ASPIRE电话指导组，+0.5%（P = 0.76）；ASPIRE小组就诊组与行动！组，-1.5%（P = 0.03）。
结论
男女混合的小组计划可使女性和男性退伍军人实现体重减轻。
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