Center for Healthcare Organization and Implementation Research, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Massachusetts, USA.
Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Medicine, School of Medicine, Boston University, Boston, Massachusetts, USA.
Obesity (Silver Spring). 2019 Jul;27(7):1168-1176. doi: 10.1002/oby.22503. Epub 2019 May 15.
Weight-management medications (WMM) are recommended for the treatment of obesity. This study examined characteristics associated with initial receipt of WMM among eligible veterans in the first year following enrollment in the Veterans Health Administration (VHA) MOVE! behavioral weight-management program.
We conducted a retrospective cohort study of VHA patients with obesity or overweight and obesity-related comorbidities who enrolled in MOVE! from October 2013 to September 2016 (N = 153,939). Multivariable logistic regression models estimated predictors of having a filled prescription for WMM and for orlistat.
A total of 1.1% of these veterans received WMM. The most common WMM included orlistat (70.4%), phentermine/topiramate (11.2%), and bupropion/naltrexone (9.7%). Female sex, higher BMI, obstructive sleep apnea, osteoarthritis, depression, lower back pain, and alcohol abuse were associated with greater odds of use of WMM, whereas age over 65 years, Hispanic ethnicity, and required co-payments were associated with lower odds. Among patients receiving WMM, older age, black race, female sex, higher BMI, cardiovascular disease, lower back pain, and congestive heart failure were associated with use of orlistat versus any other WMM.
Of patients engaged in MOVE! in the VHA, 1.1% received WMM. WMM are underutilized among veterans. Additional research is needed to understand barriers to incorporating WMM into comprehensive obesity treatment plans.
体重管理药物(WMM)被推荐用于肥胖症的治疗。本研究调查了在退伍军人事务部(VHA)MOVE!行为体重管理计划登记后的第一年,符合条件的退伍军人中,初始接受 WMM 的特征。
我们对 2013 年 10 月至 2016 年 9 月期间参加 MOVE!的肥胖或超重合并肥胖相关合并症的 VHA 患者进行了回顾性队列研究(N=153939)。多变量逻辑回归模型估计了有 WMM 处方和奥利司他处方的预测因素。
这些退伍军人中共有 1.1%接受了 WMM。最常见的 WMM 包括奥利司他(70.4%)、 phentermine/topiramate(11.2%)和 bupropion/naltrexone(9.7%)。女性、较高的 BMI、阻塞性睡眠呼吸暂停、骨关节炎、抑郁、下腰痛和酒精滥用与使用 WMM 的可能性更大相关,而年龄超过 65 岁、西班牙裔和需要共付额与可能性较小相关。在接受 WMM 的患者中,年龄较大、黑人种族、女性、较高的 BMI、心血管疾病、下腰痛和充血性心力衰竭与使用奥利司他而非任何其他 WMM 相关。
在 VHA 接受 MOVE!的患者中,有 1.1%接受了 WMM。WMM 在退伍军人中的使用率较低。需要进一步研究以了解将 WMM 纳入综合肥胖治疗计划的障碍。