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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Ghirardi O, Milano S, Ramacci M T, Angelucci L

Biological Research Laboratories, Sigma Tau S.p.A., Rome, Italy.

Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(1-2):237-45. doi: 10.1016/0278-5846(89)90021-3.

Untreated rats of different ages and old rats chronically treated with Acetyl-1-carnitine were subjected to the spatial learning task. 2. For this test, a circular pool filled with milk-opacified water was used. The animals were to reach an escape platform with the aid of visible environmental cues. 3. The experimental results indicated a clear-cut deterioration of the old animal's acquisition ability of a spatial learning task. 4. The long-term treatment (8 months) with Acetyl-1-carnitine was found to antagonize such a deterioration.

对不同年龄未治疗的大鼠以及长期用乙酰左旋肉碱治疗的老年大鼠进行空间学习任务测试。2. 在此测试中，使用一个装满乳浊化水的圆形水池。动物需借助可见的环境线索到达逃生平台。3. 实验结果表明老年动物在空间学习任务中的习得能力明显下降。4. 发现用乙酰左旋肉碱进行长期治疗（8个月）可对抗这种下降。

Ghirardi O, Milano S, Ramacci M T, Angelucci L

Biological Research Laboratories, Sigma Tau S.p.A., Rome, Italy.

Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(1-2):237-45. doi: 10.1016/0278-5846(89)90021-3.

Untreated rats of different ages and old rats chronically treated with Acetyl-1-carnitine were subjected to the spatial learning task. 2. For this test, a circular pool filled with milk-opacified water was used. The animals were to reach an escape platform with the aid of visible environmental cues. 3. The experimental results indicated a clear-cut deterioration of the old animal's acquisition ability of a spatial learning task. 4. The long-term treatment (8 months) with Acetyl-1-carnitine was found to antagonize such a deterioration.

对不同年龄未治疗的大鼠以及长期用乙酰左旋肉碱治疗的老年大鼠进行空间学习任务测试。2. 在此测试中，使用一个装满乳浊化水的圆形水池。动物需借助可见的环境线索到达逃生平台。3. 实验结果表明老年动物在空间学习任务中的习得能力明显下降。4. 发现用乙酰左旋肉碱进行长期治疗（8个月）可对抗这种下降。