Lo Buono Viviana, Corallo Francesco, Marra Angela, Calabrò Rocco Salvatore, Bramanti Placido, Marino Silvia
a IRCCS Centro Neurolesi "Bonino Pulejo" , Messina , Italy.
b Department of Biomedical and Dental Sciences and Morphofunctional Imaging , University of Messina , Messina , Italy.
Acta Clin Belg. 2016 Oct;71(5):356-358. doi: 10.1080/17843286.2016.1216260. Epub 2016 Aug 4.
Semantic dementia is one of the main clinical variants of frontotemporal dementia and it is characterized by severe loss of conceptual knowledge with relative preservation of other cortical abilities.
We described a case of a patient affected by right temporal variant of frontotemporal lobar degeneration, characterized by prosopagnosia as an unusual disease onset.
The neuropsychological evaluation showed a progressive deficit in face recognition and a slow decline in language in the absence of behavioral alterations. Magnetic resonance imaging showed diffuse vascular ischemic lesions, cortical atrophy in bilateral temporal lobes, and a marked bilateral decrease hippocampal volume, mainly involving the right side.
Our findings suggest that prosopagnosia could be a predictive marker of atypical semantic dementia onset.
语义性痴呆是额颞叶痴呆的主要临床变异型之一，其特征是概念知识严重丧失而其他皮质功能相对保留。
我们描述了一例受额颞叶变性右侧颞叶变异型影响的患者，其以面容失认作为不寻常的疾病起病特征。
神经心理学评估显示面部识别能力进行性缺陷，语言能力缓慢下降，且无行为改变。磁共振成像显示弥漫性血管缺血性病变、双侧颞叶皮质萎缩以及双侧海马体积显著减小，主要累及右侧。
我们的研究结果表明，面容失认可能是非典型语义性痴呆起病的预测标志物。
