Sone Daichi, Sato Noriko, Maikusa Norihide, Ota Miho, Sumida Kaoru, Yokoyama Kota, Kimura Yukio, Imabayashi Etsuko, Watanabe Yutaka, Watanabe Masako, Okazaki Mitsutoshi, Onuma Teiichi, Matsuda Hiroshi
Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8654, Japan.
Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.
Neuroimage Clin. 2016 Jun 13;12:57-64. doi: 10.1016/j.nicl.2016.06.008. eCollection 2016.
Automated subfield volumetry of hippocampus is desirable for use in temporal lobe epilepsy (TLE), but its utility has not been established. Automatic segmentation of hippocampal subfields (ASHS) and the new version of FreeSurfer software (ver.6.0) using high-resolution T2-weighted MR imaging are candidates for this volumetry. The aim of this study was to evaluate hippocampal subfields in TLE patients using ASHS as well as the old and new versions of FreeSurfer.
We recruited 50 consecutive unilateral TLE patients including 25 with hippocampal sclerosis (TLE-HS) and 25 without obvious etiology (TLE-nonHS). All patients and 45 healthy controls underwent high-resolution T2-weighted and 3D-volume T1-weighted MRI scanning. We analyzed all of their MR images by FreeSurfer ver.5.3, ver.6.0 and ASHS. For each subfield, normalized z-scores were calculated and compared among groups.
In TLE-HS groups, ASHS and FreeSurfer ver.6.0 revealed maximal z-scores in ipsilateral cornu ammonis (CA) 1, CA4 and dentate gyrus (DG), whereas in FreeSurfer ver.5.3 ipsilateral subiculum showed maximal z-scores. In TLE-nonHS group, there was no significant volume reduction by either ASHS or FreeSurfer.
ASHS and the new version of FreeSurfer may have an advantage in compatibility with existing histopathological knowledge in TLE patients with HS compared to the old version of FreeSurfer (ver.5.3), although further investigations with pathological findings and/or surgical outcomes are desirable.
海马体亚区容积的自动化测量在颞叶癫痫（TLE）中具有应用价值，但尚未得到证实。使用高分辨率T2加权磁共振成像对海马体亚区进行自动分割（ASHS）以及新版FreeSurfer软件（版本6.0）可用于该容积测量。本研究的目的是使用ASHS以及FreeSurfer的旧版和新版来评估TLE患者的海马体亚区。
我们连续招募了50名单侧TLE患者，其中25例有海马硬化（TLE-HS），25例无明显病因（TLE-nonHS）。所有患者和45名健康对照者均接受了高分辨率T2加权和三维容积T1加权磁共振成像扫描。我们使用FreeSurfer 5.3版、6.0版和ASHS对他们所有的磁共振图像进行了分析。对于每个亚区，计算标准化z分数并在各组之间进行比较。
在TLE-HS组中，ASHS和FreeSurfer 6.0版在同侧海马角（CA）1、CA4和齿状回（DG）中显示出最大z分数，而在FreeSurfer 5.3版中，同侧下托显示出最大z分数。在TLE-nonHS组中，ASHS或FreeSurfer均未显示出明显的体积减小。
与FreeSurfer旧版（5.3版）相比，ASHS和新版FreeSurfer在与HS型TLE患者现有组织病理学知识的兼容性方面可能具有优势，尽管需要结合病理结果和/或手术结果进行进一步研究。
