Lim Sl-Ki, Lee Yong Seok, Namkung Suk, Lim Jacqueline K, Yoon In-Kyu
International Vaccine Institute, Seoul, Korea.
Clin Exp Vaccine Res. 2016 Jul;5(2):89-100. doi: 10.7774/cevr.2016.5.2.89. Epub 2016 Jul 29.
Travel-acquired dengue cases have been increasing as the overall global dengue burden has expanded. In Korea, imported dengue cases have been reported since 2000 when it first became a notifiable disease. During the first four months of 2016, three times more dengue cases were reported in Korea than during the same period the previous year. A safe and efficacious vaccine for travelers would be beneficial to prevent dengue disease in individual travelers and potentially decrease the risk of virus spread to non-endemic areas. Here, we summarize the characteristics of dengue vaccines for travelers and review dengue vaccines currently licensed or in clinical development.
随着全球登革热总体负担的加重，旅行获得性登革热病例一直在增加。在韩国，自2000年登革热首次成为法定报告疾病以来，已有输入性登革热病例的报告。在2016年的前四个月，韩国报告的登革热病例比上一年同期多两倍。一种安全有效的旅行者疫苗将有助于预防个体旅行者感染登革热疾病，并有可能降低病毒传播到非流行地区的风险。在此，我们总结了旅行者登革热疫苗的特点，并综述了目前已获许可或正在进行临床开发的登革热疫苗。
