Montaño García M L, Orea M
Rev Alerg Mex (1987). 1989 Jan-Feb;36(1):15-8.
Certain food additives are known to induce urticaria and angioneurotic edema in susceptible patients. Thirty-three patients with chronic urticaria and angioneurotic edema whose case history suggested a possible link between exacerbations of the symptoms and ingestion of food additives or with acute exacerbations of the disease without any known triggering event were challenged orally in a double-blind study with increasing doses of the following additives: sodium benzoate, sodium metabisulfite and tartrazine and lactose as placebo. Ten of the 33 patients (30.3%) were intolerant to at least one compound. Among 132 oral provocation tests 11 (8.3%) were positive (appearance of acute urticaria/angioneurotic edema): 5 (15.1%) to sodium benzoate, 4 (12.1%) to tartrazine an 2 (6%) to sodium metabisulfite. There was no reaction to placebo and no serious reaction was observed. Under the conditions used, oral provocation tests proved to be feasible, safe and useful in the routine investigation of chronic urticaria and angioneurotic edema.
已知某些食品添加剂会在易感患者中诱发荨麻疹和血管神经性水肿。在一项双盲研究中，对33例慢性荨麻疹和血管神经性水肿患者进行口服激发试验，这些患者的病史表明症状加重与摄入食品添加剂之间可能存在关联，或者在无任何已知触发事件的情况下疾病急性加重。试验中逐渐增加以下添加剂的剂量：苯甲酸钠、焦亚硫酸钠、柠檬黄以及作为安慰剂的乳糖。33例患者中有10例（30.3%）对至少一种化合物不耐受。在132次口服激发试验中，11次（8.3%）呈阳性（出现急性荨麻疹/血管神经性水肿）：5次（15.1%）对苯甲酸钠呈阳性，4次（12.1%）对柠檬黄呈阳性，2次（6%）对焦亚硫酸钠呈阳性。对安慰剂无反应，未观察到严重反应。在所采用的条件下，口服激发试验在慢性荨麻疹和血管神经性水肿的常规调查中被证明是可行、安全且有用的。
