Genton C, Frei P C, Pécoud A
J Allergy Clin Immunol. 1985 Jul;76(1):40-5. doi: 10.1016/0091-6749(85)90802-4.
Nonsteroidal anti-inflammatory drugs and certain food or drug additives are known to induce acute bronchospasms, angioneurotic edema, and urticaria in susceptible patients. Thirty-four patients (17 with asthma and 17 with urticaria), whose case history suggested such intolerance, were challenged orally with increasing doses of seven compounds: acetylsalicylic acid, glafenine, sodium benzoate, sulfur dioxide, potassium sorbate, sodium glutamate, and tartrazine. Among 162 oral provocation tests, 38 were positive (20% decrease in peak flow rate or appearance of acute urticaria/angioneurotic edema). Twenty-four of the 34 patients (nine with asthma and 15 with urticaria) were intolerant to at least one compound. However, no serious reaction was observed. In 20 of these 24 patients (six with asthma and 14 with urticaria), a diet free of additives and nonsteroidal anti-inflammatory drugs resulted, within 5 days, in a marked improvement of symptoms, which persisted 8 to 14 mo after starting the diet. Age, prevalence of IgE-mediated allergy, and nasal polyposis were similar in patients with or without reactions of intolerance. Under the conditions used, oral provocation tests proved to be feasible, safe, and useful in many patients not helped by existing methods.
已知非甾体抗炎药以及某些食物或药物添加剂会在易感患者中诱发急性支气管痉挛、血管性水肿和荨麻疹。34例患者（17例哮喘患者和17例荨麻疹患者），其病史提示存在这种不耐受情况，对七种化合物（乙酰水杨酸、格拉非宁、苯甲酸钠、二氧化硫、山梨酸钾、谷氨酸钠和酒石黄）进行递增剂量的口服激发试验。在162次口服激发试验中，38次呈阳性（峰值流速降低20%或出现急性荨麻疹/血管性水肿）。34例患者中有24例（9例哮喘患者和15例荨麻疹患者）对至少一种化合物不耐受。然而，未观察到严重反应。在这24例患者中的20例（6例哮喘患者和14例荨麻疹患者），避免食用添加剂和非甾体抗炎药的饮食在5天内使症状显著改善，在开始饮食后症状持续改善8至14个月。有或没有不耐受反应的患者在年龄、IgE介导的过敏患病率和鼻息肉方面相似。在所采用的条件下，口服激发试验在许多现有方法无法提供帮助的患者中被证明是可行、安全且有用的。
