Cristodorescu R, Deutsch G, Drăgan S
1st Medical Clinic, Institute of Medicine, Timisoara, Romania.
Med Interne. 1989 Jan-Mar;27(1):25-32.
The results of plasma digoxin concentration (PDC) measurements in 260 patients treated with digitalis lanata preparations (digoxin, lanatoside C, betamethyl-digoxin) allowed the following observations: 1. Owing to an important overlap between "toxic" and "nontoxic" PDC values, the method has a limited value in the diagnosis of digitalis toxicity. However, in patients with toxicity associated with PDC under 2 ng/ml, it allows identification digitalis sensitivity. 2. A dosage selection based on PDC assessment led to a decrease of digitalis toxicity under 4%. As the method is not widely available, it has to be used in patients with borderline renal function, in aged subjects and in patients with rapid atrial fibrillation who require higher digitalis doses for heart rate control.
对260例接受毛花洋地黄制剂（地高辛、毛花苷C、β-甲基地高辛）治疗患者的血浆地高辛浓度（PDC）测量结果得出以下观察结论：1. 由于“中毒”和“未中毒”的PDC值有很大重叠，该方法在诊断洋地黄中毒方面价值有限。然而，对于PDC低于2 ng/ml的中毒患者，它有助于识别洋地黄敏感性。2. 根据PDC评估进行剂量选择可使洋地黄中毒率降至4%以下。由于该方法未广泛应用，它必须用于肾功能临界患者、老年患者以及需要更高洋地黄剂量来控制心率的快速心房颤动患者。
