Moszczyński P, Slowinski S, Lisiewicz J
Provincial Immunological Laboratory, Regional Hospital, Brzesko, Poland.
Med Interne. 1989 Jan-Mar;27(1):41-6.
In the peripheral blood lymphocytes of 85 men aged 18 to 42 years having smoked cigarettes for 2 to 25 years, the activity of various intracellular enzymes was determined using the semiquantitative histochemical methods. The lymphocytes of people having smoked for less than 10 years were characterized by increased acid phosphatase (AP), leucine aminopeptidase (LAP) and lactic dehydrogenase (LDH) activities whereas that of N-acetyl-beta-D-glucosaminidase (NAG) were lowered. In subjects having smoked for more than 10 years lower acid phosphatase, beta-glucuronidase, N-acetyl-beta-D-glucosaminidase and lactic dehydrogenase activities have been observed. According to the authors' suggestions, the functional lymphocyte abnormalities noted in smokers by numerous investigators may be associated with the intracellular enzymatic deficiencies.
在85名年龄在18至42岁、吸烟2至25年的男性外周血淋巴细胞中，采用半定量组织化学方法测定了各种细胞内酶的活性。吸烟少于10年者的淋巴细胞表现为酸性磷酸酶（AP）、亮氨酸氨肽酶（LAP）和乳酸脱氢酶（LDH）活性增加，而N - 乙酰 - β - D - 氨基葡萄糖苷酶（NAG）活性降低。在吸烟超过10年的受试者中，观察到酸性磷酸酶、β - 葡萄糖醛酸酶、N - 乙酰 - β - D - 氨基葡萄糖苷酶和乳酸脱氢酶活性降低。根据作者的建议，众多研究者在吸烟者中发现的功能性淋巴细胞异常可能与细胞内酶缺乏有关。
