Lisiewicz J, Moszczyński P, Palimaka W
Med Interne. 1983 Jan-Mar;21(1):31-5.
The activity and intracellular localization of some main lysosomal enzymes such as: acid phosphatase (AP), beta-glucuronidase (GR) and N-acetyl-beta-glucosaminidase (GS) in peripheral blood neutrophils and lymphocytes has been studied in a total group of 141 subjects of both sexes aged 18 to 90 years, divided into two age groups consisting of 81 younger controls aged 18 to 42 years and 60 older subjects aged 66 to 90 years. The most important finding concerning the neutrophil system was the decrease in the aged group of enzyme-positive cells not accompanied by alterations of AP and GR intracellular activity whereas the activity of GS was increased in older subjects. The lymphocytes of aged persons were characterized by lack of normal lysosomal granules and diffusion of AP, GR and GS within the cell cytoplasm. The authors discuss the above changes in the neutrophils and lymphocytes of aged persons within the overall present-day knowledge on ageing of the neutrophilic and lymphocytic series.
在141名年龄在18至90岁的男女受试者组成的总群体中，研究了外周血中性粒细胞和淋巴细胞中一些主要溶酶体酶的活性和细胞内定位，这些酶包括：酸性磷酸酶（AP）、β-葡萄糖醛酸酶（GR）和N-乙酰-β-氨基葡萄糖苷酶（GS）。该群体分为两个年龄组，其中81名年龄在18至42岁的年轻对照组，以及60名年龄在66至90岁的老年受试者。关于中性粒细胞系统的最重要发现是，老年组中酶阳性细胞减少，而AP和GR的细胞内活性没有改变，而老年受试者中GS的活性增加。老年人的淋巴细胞特征是缺乏正常的溶酶体颗粒，且AP、GR和GS在细胞质内扩散。作者结合目前关于嗜中性粒细胞和淋巴细胞系列衰老的整体知识，讨论了老年人中性粒细胞和淋巴细胞的上述变化。
