Tung Jack K, Berglund Ken, Gross Robert E
Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; Department of Neurosurgery, Emory University, Atlanta, GA.
Department of Neurosurgery, Emory University, Atlanta, GA.
Brain Stimul. 2016 Nov-Dec;9(6):801-810. doi: 10.1016/j.brs.2016.06.055. Epub 2016 Jul 14.
Optogenetics, a technique that utilizes light-sensitive ion channels or pumps to activate or inhibit neurons, has allowed scientists unprecedented precision and control for manipulating neuronal activity. With the clinical need to develop more precise and effective therapies for patients with drug-resistant epilepsy, these tools have recently been explored as a novel treatment for halting seizure activity in various animal models. In this review, we provide a detailed and current summary of these optogenetic approaches and provide a perspective on their future clinical application as a potential neuromodulatory therapy.
光遗传学是一种利用光敏离子通道或泵来激活或抑制神经元的技术，它使科学家在操纵神经元活动方面获得了前所未有的精确性和控制权。鉴于临床上需要为耐药性癫痫患者开发更精确有效的治疗方法，最近人们对这些工具进行了探索，将其作为在各种动物模型中阻止癫痫发作活动的一种新疗法。在这篇综述中，我们详细且全面地总结了这些光遗传学方法，并对其作为一种潜在的神经调节疗法的未来临床应用提出了看法。
