Ayurvidye Trust, Giri Nagar, Bengaluru 560085, Karnataka, India.
Ayurvidye Trust, Giri Nagar, Bengaluru 560085, Karnataka, India.
J Ethnopharmacol. 2017 Feb 2;197:52-60. doi: 10.1016/j.jep.2016.07.078. Epub 2016 Aug 2.
Chyawanprash (CP), a traditional immune booster recipe, has a long history of ethnic origin, development, household preparation and usage. There are even mythological stories about the origin of this recipe including its nomenclature. In the last six decades, CP, because of entrepreneurial actions of some research Vaidyas (traditional doctors) has grown to industrial production and marketing in packed forms to a large number of consumers/patients like any food or health care product. Currently, CP has acquired a large accepted user base in India and in a few countries out-side India.
Authoritative texts, recognized by the Drugs and Cosmetics Act of India, describe CP as an immunity enhancer and strength giver meant for improving lung functions in diseases with compromised immunity. This review focuses on published clinical efficacy and safety studies of CP for correlation with health benefits as documented in the authoritative texts, and also briefs on its recipes and processes.
Authoritative texts were searched for recipes, processes, and other technical details of CP. Labels of marketing CP products (Indian) were studied for the health claims. Electronic search for studies of CP on efficacy and safety data were performed in PubMed/MEDLINE and DHARA (Digital Helpline for Ayurveda Research Articles), and Ayurvedic books were also searched for clinical studies.
The documented clinical studies from electronic databases and Ayurvedic books evidenced that individuals who consume CP regularly for a definite period of time showed improvement in overall health status and immunity. However, most of the clinical studies in this review are of smaller sample size and short duration. Further, limitation to access and review significant data on traditional products like CP in electronic databases was noted.
Randomized controlled trials of high quality with larger sample size and longer follow-up are needed to have significant evidence on the clinical use of CP as immunity booster. Additional studies involving measurement of current biomarkers of immunity pre- and post-consumption of the product as well as benefits accruing with the use of CP as an adjuvant are suggested.
恰瓦普（CP）是一种传统的免疫增强配方，具有悠久的民族起源、发展、家庭制备和使用历史。甚至有关于这个配方起源的神话故事，包括它的命名。在过去的六十年里，由于一些研究吠陀医生（传统医生）的创业行动，CP 已经发展到以包装形式进行工业化生产和营销，为数以千计的消费者/患者（如任何食品或保健品）提供服务。目前，CP 在印度和少数印度以外的国家拥有大量的认可用户群体。
印度药品和化妆品法案认可的权威文本将 CP 描述为一种增强免疫力和增强体力的药物，旨在改善免疫力受损疾病中的肺部功能。本综述重点关注 CP 的已发表临床疗效和安全性研究，以与权威文本中记录的健康益处相关联，并简要介绍其配方和工艺。
搜索了 CP 的配方、工艺和其他技术细节的权威文本。研究了印度 CP 营销产品的标签，以了解其健康声称。在 PubMed/MEDLINE 和 DHARA（数字阿育吠陀研究文章热线）中进行了关于 CP 疗效和安全性数据的电子搜索，并搜索了阿育吠陀书籍中的临床研究。
从电子数据库和阿育吠陀书籍中获得的已记录临床研究表明，经常定期食用 CP 的个体在整体健康状况和免疫力方面都有所改善。然而，本综述中的大多数临床研究样本量较小且持续时间较短。此外，还注意到在电子数据库中对传统产品（如 CP）进行访问和审查重要数据的限制。
需要进行高质量的随机对照试验，样本量更大，随访时间更长，才能获得 CP 作为免疫增强剂的临床使用的显著证据。建议进行额外的研究，包括在产品消费前后测量当前免疫生物标志物，以及使用 CP 作为佐剂带来的益处。
