Lawrence Monica G, Woodfolk Judith A, Schuyler Alexander J, Stillman Leland C, Chapman Martin D, Platts-Mills Thomas A E
University of Virginia Asthma and Allergic Diseases Center, Charlottesville, Va.
Indoor Biotechnologies, Charlottesville, Va.
J Allergy Clin Immunol. 2017 Feb;139(2):422-428.e4. doi: 10.1016/j.jaci.2016.04.056. Epub 2016 Jul 14.
We present results from clinical studies on plasma infusion done in the late 1970s in patients with hypogammaglobulinemia in which we documented the short half-life of both total and allergen-specific IgE in serum. The development of specific allergic sensitization in the skin of those patients followed by the gradual decrease in sensitization over 50 days was also documented. The data are included here along with a discussion of the existing literature about the half-life of IgE in both the circulation and skin. This rostrum reinterprets the earlier clinical studies in light of new insights and mechanisms that could explain the rapid removal of IgE from the circulation. These mechanisms have clinical implications that relate to the increasing use of anti-IgE mAbs for the treatment of allergic disease.
我们展示了20世纪70年代末针对低丙种球蛋白血症患者进行的血浆输注临床研究结果，在这些研究中，我们记录了血清中总IgE和过敏原特异性IgE的短半衰期。还记录了这些患者皮肤中特异性过敏致敏的发展情况，以及在50天内致敏逐渐降低的情况。此处纳入了这些数据，并讨论了关于循环系统和皮肤中IgE半衰期的现有文献。鉴于能够解释IgE从循环系统中快速清除的新见解和机制，本报告重新解读了早期的临床研究。这些机制具有临床意义，与抗IgE单克隆抗体在过敏性疾病治疗中的日益广泛应用相关。
