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社区层面的处方阿片类药物过量使用与儿童伤害有关吗?对2001年至2011年加利福尼亚州邮政编码区域的空间分析。

Are community level prescription opioid overdoses associated with child harm? A spatial analysis of California zip codes, 2001-2011.

作者信息

Wolf Jennifer Price, Ponicki William R, Kepple Nancy J, Gaidus Andrew

机构信息

Division of Social Work, California State University, Sacramento 600 J Street, Sacramento, CA 95812, United States; Pacific Institute for Research and Evaluation, Prevention Research Center, 180 Grand Avenue, Oakland, CA 94612, United States.

Pacific Institute for Research and Evaluation, Prevention Research Center, 180 Grand Avenue, Oakland, CA 94612, United States.

出版信息

Drug Alcohol Depend. 2016 Sep 1;166:202-8. doi: 10.1016/j.drugalcdep.2016.07.014. Epub 2016 Jul 26.

Abstract

BACKGROUND

Non-medical prescription opioid use is increasing globally within high-income countries, particularly the United States. However, little is known about whether it is associated with negative outcomes for children. In this study, we use prescription opioid overdose as a proxy measure for non-medical prescription opioid use and ask the following: Do California communities with greater rates of non-medical prescription opioid use also have higher rates of child maltreatment and unintentional child injury?

METHODS

We used longitudinal population data to examine ecological associations between hospital discharges involving overdose of prescription opioids and those for child maltreatment or child injury in California zip codes between 2001 and 2011 (n=18,517 zip-code year units) using Bayesian space-time misalignment models.

RESULTS

The percentage of hospital discharges involving prescription opioid overdose was positively associated with the number of hospital discharges for child maltreatment (relative rate=1.089, 95% credible interval (1.004, 1.165)) and child injury (relative rate=1.055, 95% credible interval (1.012, 1.096)) over the ten-year period, controlling for other substance use and environmental factors.

CONCLUSIONS

Increases in community level prescription opioid overdoses between 2001 and 2011 are associated with a 2.06% increase in child maltreatment discharges and a 1.27% increase in discharges for child injury. Communities with higher rates of non-medical prescription opioid use may experience greater levels of child harms.

摘要

背景

在全球范围内,高收入国家,尤其是美国,非医疗用途的处方阿片类药物使用呈上升趋势。然而,对于其是否与儿童负面后果相关却知之甚少。在本研究中,我们将处方阿片类药物过量使用作为非医疗用途处方阿片类药物使用的替代指标,并提出以下问题:非医疗用途处方阿片类药物使用率较高的加利福尼亚社区,其儿童虐待和儿童意外伤害发生率是否也更高?

方法

我们使用纵向人口数据,通过贝叶斯时空错位模型,研究2001年至2011年加利福尼亚邮政编码区域(n = 18,517个邮政编码年份单位)中涉及处方阿片类药物过量使用的医院出院情况与儿童虐待或儿童伤害的医院出院情况之间的生态关联。

结果

在控制了其他物质使用和环境因素后,在这十年期间,涉及处方阿片类药物过量使用的医院出院百分比与儿童虐待的医院出院数量(相对率 = 1.089,95%可信区间(1.004, 1.165))以及儿童伤害的医院出院数量(相对率 = 1.055,95%可信区间(1.012, 1.096))呈正相关。

结论

2001年至2011年社区层面处方阿片类药物过量使用的增加与儿童虐待出院率增加2.06%以及儿童伤害出院率增加1.27%相关。非医疗用途处方阿片类药物使用率较高的社区可能会经历更严重的儿童伤害。

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