Bazmamoun Hassan, Rafeey Mandana, Nikpouri Maryam, Ghergherehchi Robabeh
Department of Pediatric, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Liver and Gastrointestinal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Res Health Sci. 2016 Spring;16(2):68-71.
Helicobacter pylori infection is one of the most common chronic bacterial infections. There is challenge on the real rate of prevalence of H. pylori in diabetic patients. This study was done to assess the prevalence of H. pylori infection in children suffering from type 1 insulin-dependent diabetes mellitus.
In this case-control study, 80 diabetic patients (as the target group) refer to the Endocrinology Clinic of Tabriz Educational and Treatment Center, Tabriz northwestern Iran and 80 non-diabetic patients (as the control group) from the group of children referring to the GI Clinic of the same center were enrolled in 2012 and 2013. Then H. pylori infection was assessed in two groups using measuring antibody (IgG) and stool antigen (HpSA).
H. pylori infection tests were positive in 48 (60%) diabetic patients and in 32 (40%) in non-diabetic patients (P=0.030). There was a meaningful correlation between the frequency of H. pylori and the longer the duration of diabetes (P<0.001). No correlation was seen between H. pylori infection and other factors such as age of the patients (P=0.840), HbA1C level (P=0.312), age at which diabetes was diagnosed (P=0.800), average daily dosage of insulin (P=0.232), and presence of GI symptoms (P=0.430).
Type 1 diabetic children especially cases with the longer duration of diabetes, are at risk acquiring H. pylori infection. Therefore, screening of H. pylori infection is helpful on the follow up of these patients.
幽门螺杆菌感染是最常见的慢性细菌感染之一。糖尿病患者中幽门螺杆菌的实际感染率存在争议。本研究旨在评估1型胰岛素依赖型糖尿病患儿中幽门螺杆菌感染的患病率。
在这项病例对照研究中，2012年和2013年纳入了80例糖尿病患者（作为目标组），他们来自伊朗西北部大不里士教育与治疗中心的内分泌诊所，以及80例非糖尿病患者（作为对照组），他们来自同一中心胃肠病诊所的儿童群体。然后，使用测量抗体（IgG）和粪便抗原（HpSA）对两组进行幽门螺杆菌感染评估。
48例（60%）糖尿病患者的幽门螺杆菌感染检测呈阳性，32例（40%）非糖尿病患者呈阳性（P=0.030）。幽门螺杆菌感染频率与糖尿病病程越长之间存在显著相关性（P<0.001）。未发现幽门螺杆菌感染与患者年龄（P=0.840）、糖化血红蛋白水平（P=0.312）、糖尿病诊断年龄（P=0.800）、胰岛素日均剂量（P=0.232）和胃肠道症状的存在（P=0.430）等其他因素之间存在相关性。
1型糖尿病儿童，尤其是糖尿病病程较长的患儿，有感染幽门螺杆菌的风险。因此，筛查幽门螺杆菌感染有助于对这些患者进行随访。
