Bener Abdulbari, Micallef Rosetta, Afifi Mustafa, Derbala Moutaz, Al-Mulla Hamad M, Usmani M Asad
Hamad General Hospital, Hamad Medical Corporation Doha, Department of Medical Statistics and Epidemiology, State of Qatar.
Turk J Gastroenterol. 2007 Dec;18(4):225-9.
BACKGROUND/AIMS: It is well known that patients with diabetes mellitus are more prone to infection. In patients with diabetes mellitus, chronic infections are frequent and severe, due to the impairment of their immune status. The aim of this study was to determine the association between Helicobacter pylori infection and type 2 diabetes mellitus in the United Arab Emirates population. This is a case and control study comparison of type 2 diabetes mellitus and non-diabetic groups. The study was conducted at the primary health care clinics in United Arab Emirates during the period from June 2002 to August 2003. The study included 210 type 2 diabetes mellitus patients and 210 non-diabetic subjects.
Helicobacter pylori was assessed by histopathological examination by measuring antibody profiles (IgG and IgA) among type 2 diabetes mellitus patients and the non-diabetic group.
The mean age of type 2 diabetes mellitus patients infected with Helicobacter pylori was 48.1 +/- 7.9 years compared to 46.7 +/- 5.4 years in the non-diabetic infected subjects. A positive antibody titer for Helicobacter pylori infection (IgA >or=300) was found in 76.7% of the diabetic subjects compared to 64.8% of the non-diabetic subjects (p<0.009). There was higher prevalence of Helicobacter pylori infection in diabetic obese patients than the non-diabetic subjects (23.6% vs 11.8%, p<0.001). Muscular (47.2%), gastrointestinal (29.8%), chronic bronchitis (22.4%), nausea (19.9%), anemia (18%), abdominal pain (12.4%), diarrhea (10.6%) and vomiting (7.5%) were more common in diabetic patients infected with Helicobacter pylori.
The present study suggests that there is a significant association between Helicobacter pylori infection and type 2 diabetes mellitus. Helicobacter pylori infection was significantly higher in diabetic obese patients than non-diabetic subjects.
背景/目的：众所周知，糖尿病患者更容易感染。在糖尿病患者中，由于免疫状态受损，慢性感染频繁且严重。本研究的目的是确定阿拉伯联合酋长国人群中幽门螺杆菌感染与2型糖尿病之间的关联。这是一项2型糖尿病组与非糖尿病组的病例对照研究。该研究于2002年6月至2003年8月在阿拉伯联合酋长国的初级卫生保健诊所进行。研究包括210名2型糖尿病患者和210名非糖尿病受试者。
通过组织病理学检查评估幽门螺杆菌，并测量2型糖尿病患者和非糖尿病组的抗体谱（IgG和IgA）。
感染幽门螺杆菌的2型糖尿病患者的平均年龄为48.1±7.9岁，而未感染的非糖尿病受试者的平均年龄为46.7±5.4岁。76.7%的糖尿病受试者幽门螺杆菌感染抗体滴度呈阳性（IgA≥300），相比之下，非糖尿病受试者的这一比例为64.8%（p<0.009）。糖尿病肥胖患者中幽门螺杆菌感染的患病率高于非糖尿病受试者（23.6%对11.8%，p<0.001）。感染幽门螺杆菌的糖尿病患者中，肌肉（47.2%）、胃肠道（29.8%）、慢性支气管炎（22.4%）、恶心（19.9%）、贫血（18%）、腹痛（12.4%）、腹泻（10.6%）和呕吐（7.5%）更为常见。
本研究表明幽门螺杆菌感染与2型糖尿病之间存在显著关联。糖尿病肥胖患者中幽门螺杆菌感染明显高于非糖尿病受试者。
