Division of Pediatric Endocrinology, Department of Pediatrics, Tungs' Taichung MetroHarbor Hospital, Taichung 43503, Taiwan.
Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Medicina (Kaunas). 2024 Jan 9;60(1):119. doi: 10.3390/medicina60010119.
: Type 1 diabetes mellitus (T1DM) is a chronic and serious condition that is characterized by inadequate pancreatic-β-cells' insulin production. The connection between T1DM and infection remains uncertain. This study aimed to conduct a systematic meta-analysis to examine the association between infection, hemoglobin A1c levels, and the development of T1DM. : The initial search identified 451 articles on the association between infection and T1DM. Among them, 12 articles had 2797 participants who met the inclusion criteria for an advanced meta-analysis. : A significant association was observed between infection and T1DM (OR 1.77, 95% CI 1.47-2.12, < 0.0001), with heterogeneity: Tau = 0.47; Chi = 57.07, df = 11 ( < 0.0001); I = 81%. Subgroup analysis showed that infection was significantly associated with a longer duration of T1DM and higher hemoglobin A1c levels ( < 0.001 for both) but not with age at T1DM diagnosis ( = 0.306). These findings contribute to the understanding of the association between infection and T1DM and highlight the potential role of in influencing the duration and glycemic control of diabetes. Therefore, pediatric patients who have longstanding T1DM and poor glycemic control should be screened for infection.
1 型糖尿病（T1DM）是一种慢性且严重的疾病，其特征是胰腺β细胞胰岛素产生不足。T1DM 与感染之间的联系仍不确定。本研究旨在进行系统的荟萃分析，以检查感染、糖化血红蛋白水平与 T1DM 发病之间的关系。
最初的搜索确定了 451 篇关于感染与 T1DM 之间关系的文章。其中，有 12 篇文章有 2797 名参与者符合高级荟萃分析的纳入标准。
感染与 T1DM 之间存在显著关联（OR 1.77，95%CI 1.47-2.12，<0.0001），存在异质性：Tau = 0.47；Chi = 57.07，df = 11（<0.0001）；I = 81%。亚组分析表明，感染与 T1DM 持续时间较长和糖化血红蛋白水平较高显著相关（两者均<0.001），但与 T1DM 诊断时的年龄无关（=0.306）。
这些发现有助于理解感染与 T1DM 之间的关系，并强调了感染在影响糖尿病持续时间和血糖控制方面的潜在作用。因此，患有长期 T1DM 和血糖控制不佳的儿科患者应筛查感染。
