儿童幽门螺杆菌感染与1型糖尿病

Helicobacter pylori infection and type 1 diabetes mellitus in children.

作者信息

Esmaeili Dooki Mohammad Reza, Alijanpour Aghamaleki Morteza, Noushiravani Negar, Hosseini Seyed Reza, Moslemi Leila, Hajiahmadi Mahmoud, Pournasrollah Mohammad

机构信息

Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran.

Non-Communicable Pediatric Diseases Research Center, Amirkola Children's Hospital, No 19, Amirkola, Babol, Mazandaran Province 47317-41151 IR Iran.

出版信息

J Diabetes Metab Disord. 2020 Feb 4;19(1):243-247. doi: 10.1007/s40200-020-00497-1. eCollection 2020 Jun.

DOI:10.1007/s40200-020-00497-1

PMID:32550173

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7270306/

Abstract

OBJECTIVES

This study aimed to investigate the association between Helicobacter pylori infection with diabetes mellitus type one and the effect of infected Helicobacter pylori on glycemic control.

METHODS

This case control study was conducted on children with and without type 1 diabetes mellitus (T1DM). Demographic data and gastrointestinal symptoms in both groups and glycemic control status and duration of diabetes were recorded in patients with T1DM. Stool test was done on all children to detect Helicobacter pylori antigen.

RESULTS

Sixty three children with T1DM with a mean of 10.88 ± 2.84 years and 105 control children with an average age 10.17 ± 2.55 years ( = 0/09) were involved in this study. The frequency of Helicobacter pylori infection in patients with T1DM was 17/63 (27%) and 25/105 (23.8%) in control group, ( = 0/64). The frequency of bloating, epigastric pain and nausea was not significantly different between the two groups. The frequency of epigastric pain in children with diabetes with helicobacter infection was significantly higher than non-infected children with diabetes (29.4% vs. 2.2%) ( = 0.004).The mean duration of diabetes ( = 0.53), age diagnosis of diabetes ( = 0.09), fasting blood glucose ( = 0.18), glycosylated hemoglobin ( = 0.08) and the daily insulin dose ( = 0.18) in patients with T1DM with and without helicobacter pylori infection had not significantly different.

CONCLUSIONS

There was no significant association between Helicobacter pylori infection and diabetes in children 5-15 years old, and glycemic control status was not difference in patients with T1DM with and without Helicobacter pylori infection.

摘要

目的

本研究旨在调查幽门螺杆菌感染与1型糖尿病之间的关联以及感染幽门螺杆菌对血糖控制的影响。

方法

本病例对照研究针对患有和未患有1型糖尿病（T1DM）的儿童进行。记录两组的人口统计学数据和胃肠道症状，以及T1DM患者的血糖控制状况和糖尿病病程。对所有儿童进行粪便检测以检测幽门螺杆菌抗原。

结果

本研究纳入了63名平均年龄为10.88±2.84岁的T1DM儿童和105名平均年龄为10.17±2.55岁的对照儿童（P=0.09）。T1DM患者中幽门螺杆菌感染率为17/63（27%），对照组为25/105（23.8%），（P=0.64）。两组之间腹胀、上腹痛和恶心的发生率无显著差异。幽门螺杆菌感染的糖尿病儿童中上腹痛的发生率显著高于未感染幽门螺杆菌的糖尿病儿童（29.4%对2.2%）（P=0.004）。幽门螺杆菌感染和未感染的T1DM患者的糖尿病平均病程（P=0.53）、糖尿病诊断年龄（P=0.09）、空腹血糖（P=0.18）、糖化血红蛋白（P=0.08）和每日胰岛素剂量（P=0.18）无显著差异。