Wang Hong-Ni, Dong Wen-Hua, Huang Sheng-Zhuo, Li Wei, Kong Fan-Dong, Wang Hao, Wang Jun, Mei Wen-Li, Dai Hao-Fu
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China; Horticultural and Garden College, Hainan University, Haikou 570228, PR China.
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
Fitoterapia. 2016 Oct;114:7-11. doi: 10.1016/j.fitote.2016.07.014. Epub 2016 Aug 5.
Three new sesquiterpenoids (1-3), together with two known ones were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. The new compounds were elucidated on the basis of spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 1-5 were isolated from agarwood of A. crassna for the first time. In the acetylcholinesterase inhibition experiment of 2-5, compound 3 showed acetylcholinesterase inhibition activity (IR 42.9±0.6%). Compound 5 expressed antibacterial activities against Staphylococcus aureus and Ralstonia solanacearum with diameter of the inhibition zones of 12.35±0.11mm and 16.90±0.09mm, respectively.
从瑞香科植物沉香（Aquilaria crassna）的沉香木乙酸乙酯提取物中分离出三种新的倍半萜（1-3）以及两种已知化合物。通过光谱技术（紫外、红外、质谱、一维和二维核磁共振）对新化合物进行了结构解析。化合物1-5首次从瑞香科植物沉香的沉香木中分离得到。在对化合物2-5的乙酰胆碱酯酶抑制实验中，化合物3表现出乙酰胆碱酯酶抑制活性（抑制率为42.9±0.6%）。化合物5对金黄色葡萄球菌和青枯雷尔氏菌具有抗菌活性，抑菌圈直径分别为12.35±0.11毫米和16.90±0.09毫米。
