确定区分产碳青霉烯酶和不产碳青霉烯酶的耐碳青霉烯类肠杆菌科细菌的最佳碳青霉烯类最低抑菌浓度
Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae.
作者信息
Tamma Pranita D, Huang Yanjie, Opene Belita N A, Simner Patricia J
机构信息
Division of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
出版信息
Antimicrob Agents Chemother. 2016 Sep 23;60(10):6425-9. doi: 10.1128/AAC.00838-16. Print 2016 Oct.
Abstract
Carbapenemase-producing (CP) Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort of 198 CRE isolates, for isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC of 0.5 μg/ml and meropenem, imipenem, and doripenem MICs of 2 μg/ml were best able to distinguish CP-CRE from non-CP-CRE isolates.
摘要
产碳青霉烯酶（CP）的肠杆菌科细菌在很大程度上导致了耐碳青霉烯类肠杆菌科细菌（CRE）的迅速传播。区分产碳青霉烯酶的耐碳青霉烯类肠杆菌科细菌（CP-CRE）和非产碳青霉烯酶的耐碳青霉烯类肠杆菌科细菌（non-CP-CRE）对感染控制具有重要意义。在一组198株CRE分离株中，对于那些对某些碳青霉烯类抗生素仍敏感或中介的分离株，厄他培南的最低抑菌浓度（MIC）为0.5μg/ml，美罗培南、亚胺培南和多利培南的MIC为2μg/ml时，最能区分CP-CRE和non-CP-CRE分离株。
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本文引用的文献
1
The Prevalence and Molecular Epidemiology of Multidrug-Resistant Enterobacteriaceae Colonization in a Pediatric Intensive Care Unit.
Infect Control Hosp Epidemiol. 2016 May;37(5):535-43. doi: 10.1017/ice.2016.16. Epub 2016 Feb 9.
2
Infection control implications of heterogeneous resistance mechanisms in carbapenem-resistant Enterobacteriaceae (CRE).
Expert Rev Anti Infect Ther. 2016;14(1):95-108. doi: 10.1586/14787210.2016.1106940. Epub 2015 Nov 4.
3
Improved Phenotype-Based Definition for Identifying Carbapenemase Producers among Carbapenem-Resistant Enterobacteriaceae.
Emerg Infect Dis. 2015 Sep;21(9):1611-6. doi: 10.3201/eid2109.150198.
4
Evaluation of the Carba NP test for rapid detection of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 2013 Sep;57(9):4578-80. doi: 10.1128/AAC.00878-13. Epub 2013 Jul 1.
5
Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae.
J Clin Microbiol. 2012 Feb;50(2):477-9. doi: 10.1128/JCM.05247-11. Epub 2011 Nov 23.
6
Global spread of Carbapenemase-producing Enterobacteriaceae.
Emerg Infect Dis. 2011 Oct;17(10):1791-8. doi: 10.3201/eid1710.110655.
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