Coryell W, Endicott J, Keller M, Andreasen N, Grove W, Hirschfeld R M, Scheftner W
National Institute of Mental Health Collaborative Program on the Psychobiology of Depression--Clinical Studies, Iowa City, IA.
Am J Psychiatry. 1989 Aug;146(8):983-8. doi: 10.1176/ajp.146.8.983.
The authors studied 442 probands with nonbipolar major depression, 64 with bipolar II disorder, and 88 with bipolar I disorder. Although the proband groups did not differ in occupational or educational achievement, the first-degree relatives of probands with bipolar disorders had significantly higher mean levels of achievement than did those of probands with nonbipolar disorder. This pattern applied whether or not the relatives themselves had bipolar illness. The authors conclude that the socioeconomic advantage previously associated with affective disorder in general may be limited to the bipolar forms.
作者研究了442名患有非双相重度抑郁症的先证者、64名患有双相II型障碍的患者以及88名患有双相I型障碍的患者。尽管先证者组在职业成就或教育成就方面没有差异，但双相情感障碍先证者的一级亲属的平均成就水平显著高于非双相情感障碍先证者的一级亲属。无论亲属自身是否患有双相情感障碍，这种模式都适用。作者得出结论，先前普遍与情感障碍相关的社会经济优势可能仅限于双相情感障碍形式。
