Heun R, Maier W
Department of Psychiatry, University of Mainz, Germany.
Acta Psychiatr Scand. 1993 Apr;87(4):279-84. doi: 10.1111/j.1600-0447.1993.tb03372.x.
The aim of the study was to differentiate bipolar II, bipolar I and recurrent unipolar depression by their familial load for affective disorders. Eighty bipolar, 108 unipolar, 80 control subjects and interviewed first-degree relatives were diagnosed according to Research Diagnostic Criteria using the Schedule for Affective Disorders and Schizophrenia--lifetime version. The morbid risks for bipolar I disorder were equivalent in relatives of bipolar I (3.6%) and bipolar II (3.5%) subjects and lower in relatives of unipolar subjects (1.0%). The morbid risks of relatives for bipolar II disorder distinguished bipolar II subjects (6.1%) from bipolar I subjects (1.8%), from unipolar depressives (0.3%) and from controls (0.5%). To promote further evaluation, bipolar II disorder should be included in DSM-IV as a distinct diagnostic category.
本研究的目的是通过情感障碍的家族负荷来区分双相II型、双相I型和复发性单相抑郁症。根据研究诊断标准，使用情感障碍和精神分裂症检查表（终生版），对80名双相情感障碍患者、108名单相情感障碍患者、80名对照受试者及其一级亲属进行访谈并诊断。双相I型障碍在双相I型（3.6%）和双相II型（3.5%）受试者的亲属中的患病风险相当，而在单相受试者的亲属中较低（1.0%）。双相II型障碍亲属的患病风险将双相II型受试者（6.1%）与双相I型受试者（1.8%）、单相抑郁症患者（0.3%）和对照者（0.5%）区分开来。为促进进一步评估，双相II型障碍应作为一个独特的诊断类别纳入《精神疾病诊断与统计手册》第四版。
