Shaikh Fouzia, Jamal Qamar, Baig Saeeda, Hadi Naila Irum, Majeed Noman
Pathology, Ziauddin University, Karachi, Pakistan Email :
Asian Pac J Cancer Prev. 2016;17(7):3363-7.
Breast cancer (BC) is a major health issue worldwide as well as in Pakistan. All women belonging to any race, ethnicity or lineage are in danger of developing breast cancer. Significant factors influencing the development of breast malignancies are the genetic background, environmental conditions, reproductive parameters, the consequences of female hormones both intrinsic and extrinsic, alteration of immune status, and biologic determinants.
Overall 150 biopsy proven patients were included in the study. Samples were submitted for histopathology and determination of estrogen and progesterone receptor expression and HER2/neu status. Associations with other characteristics like age, tumor stage, node involvement, histological grade were also studied.
Mean age at presentation was 46.7 years. The majority had invasive ductal carcinoma, 100 (84.7%), and were in stage pT3, 54 (45.7%). Important relationships (P<0.05) were found among ER, PR positivity, and Her 2 neu overexpression. However, no noteworthy link was identified amongst ER, PR, Her 2 neu and tumor grade, stage, age, lymph node involvement except for the menopausal status.
In summary, breast cancer patients featured an advanced stage of disease, more lymph node involvement, and moderately high grade tumors and with more estrogen, progesterone receptor and HER2 positive tumors.
乳腺癌在全球以及巴基斯坦都是一个重大的健康问题。所有种族、族裔或血统的女性都有患乳腺癌的风险。影响乳腺恶性肿瘤发生发展的重要因素包括遗传背景、环境条件、生殖参数、体内外女性激素的影响、免疫状态改变以及生物学决定因素。
本研究共纳入150例经活检证实的患者。样本被送去进行组织病理学检查以及雌激素和孕激素受体表达及HER2/neu状态的检测。还研究了与年龄、肿瘤分期、淋巴结受累情况、组织学分级等其他特征的相关性。
就诊时的平均年龄为46.7岁。大多数患者为浸润性导管癌，有100例（84.7%），处于pT3期的有54例（45.7%）。在雌激素受体（ER）、孕激素受体（PR）阳性与HER2 neu过表达之间发现了重要关系（P<0.05）。然而，除了绝经状态外，未发现ER、PR、HER2 neu与肿瘤分级、分期、年龄、淋巴结受累情况之间有显著关联。
总之，乳腺癌患者的疾病分期较晚，淋巴结受累更多，肿瘤分级中等偏高，且雌激素、孕激素受体及HER2阳性肿瘤较多。
