Fang Ferric C, Frawley Elaine R, Tapscott Timothy, Vázquez-Torres Andrés
Department of Microbiology, University of Washington School of Medicine, Seattle, WA, 98195, USA.
Department Laboratory Medicine, University of Washington School of Medicine, Seattle, WA, 98195, USA.
Cell Host Microbe. 2016 Aug 10;20(2):144-153. doi: 10.1016/j.chom.2016.07.010.
For pathogenic bacteria, the ability to sense and respond to environmental stresses encountered within the host is critically important, allowing them to adapt to changing conditions and express virulence genes appropriately. This review considers the diverse molecular mechanisms by which stress conditions are sensed by bacteria, how related signals are discriminated, and how stress responses are integrated, highlighting recent studies in selected bacterial pathogens of clinical relevance.
对于致病细菌而言，感知并应对宿主体内遇到的环境压力的能力至关重要，这使它们能够适应不断变化的条件并适当地表达毒力基因。本综述探讨了细菌感知压力条件的多种分子机制、如何区分相关信号以及如何整合应激反应，并重点介绍了在具有临床相关性的特定细菌病原体方面的最新研究。
