Zhao Wenya, Zheng Shikan, Ye Chengsong, Li Jianguo, Yu Xin
College of the Environment and Ecology, Xiamen University, Xiamen, 361102, China.
Fujian Key Laboratory of Coastal Pollution Prevention and Control, Xiamen, 361102, China.
Environ Sci Ecotechnol. 2024 Aug 3;22:100475. doi: 10.1016/j.ese.2024.100475. eCollection 2024 Nov.
The increase in bacterial antibiotic resistance poses a significant threat to the effectiveness of antibiotics, and there is growing evidence suggesting that global warming may speed up this process. However, the direct influence of temperature on the development of antibiotic resistance and the underlying mechanisms is not yet fully understood. Here we show that antibiotic resistance exhibits a nonlinear response to elevated temperatures under the combined stress of temperatures and antibiotics. We find that the effectiveness of gatifloxacin against significantly diminishes at 42 °C, while resistance increases 256-fold at 27 °C. Additionally, the increased transcription levels of genes such as , , and with rising temperatures, along with gene mutations at different sites, explain the observed variability in resistance patterns. These findings highlight the complexity of antibiotic resistance evolution and the urgent need for comprehensive studies to understand and mitigate the effects of global warming on antibiotic resistance.
细菌对抗生素耐药性的增加对抗生素的有效性构成了重大威胁，越来越多的证据表明全球变暖可能会加速这一过程。然而，温度对抗生素耐药性发展的直接影响及其潜在机制尚未完全了解。在此，我们表明在温度和抗生素的联合胁迫下，抗生素耐药性对温度升高呈现非线性响应。我们发现加替沙星在42°C时对[具体细菌]的有效性显著降低，而在27°C时耐药性增加了256倍。此外，随着温度升高，[相关基因名称]等基因的转录水平增加，以及不同位点的基因突变，解释了观察到的耐药模式变化。这些发现凸显了抗生素耐药性进化的复杂性，以及迫切需要进行全面研究以了解和减轻全球变暖对抗生素耐药性的影响。
