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西红花苷和藏红花醛对大鼠脑室内注射组胺诱导的打哈欠的影响。

The effects of crocin and safranal on the yawning induced by intracerebroventricular injection of histamine in rats.

作者信息

Taati Mina, Tamaddonfard Esmaeal, Erfanparast Amir, Ghasemi Hamid

机构信息

Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia 57153-1177, Iran.

出版信息

Avicenna J Phytomed. 2016 Jul-Aug;6(4):442-8.

PMID:27516985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4967840/
Abstract

OBJECTIVE

Crocin and safranal, as the major constituents of saffron, have many biological activities. This study investigated the effects of crocin and safranal on yawning response induced by intracerebroventricular (i.c.v.) injection of histamine in rats.

MATERIALS AND METHODS

In ketamine/xylazine-anesthetized rats, a guide cannula was implanted in the right ventricle of the brain and yawning induced by i.c.v. injection of histamine. Crocin and safranal were intraperitoneally (i.p.) injected alone and before i.c.v. injection of histamine.

RESULTS

Histamine at the doses of 10 and 20 µg/rat produced yawning. Mepyramine (a histamine H1 receptor antagonist) 40 µg/rat significantly (p<0.05) prevented histamine (20 µg/rat)-induced yawning. Crocin (30 mg/kg) and safranal (1 mg/kg) significantly (p<0.05) increased histamine (10 µg/rat)-induced yawning. Crocin and safranal also induced yawning when injected before mepyramine plus histamine administration.

CONCLUSION

The results of the present study showed a yawning-inducing effect for central histamine, which was inhibited by mepyramine. Crocin and safranal increased histamine-induced yawning, and also produced yawning when the histamine action is blocked.

摘要

目的

西红花苷和藏红花醛作为藏红花的主要成分，具有多种生物活性。本研究调查了西红花苷和藏红花醛对大鼠脑室内注射组胺诱导的打哈欠反应的影响。

材料与方法

在氯胺酮/赛拉嗪麻醉的大鼠中，将引导套管植入右侧脑室，并通过脑室内注射组胺诱导打哈欠。西红花苷和藏红花醛单独腹腔注射以及在脑室内注射组胺之前腹腔注射。

结果

剂量为10和20μg/大鼠的组胺可引起打哈欠。40μg/大鼠的美吡拉敏（一种组胺H1受体拮抗剂）显著（p<0.05）抑制组胺（20μg/大鼠）诱导的打哈欠。西红花苷（30mg/kg）和藏红花醛（1mg/kg）显著（p<0.05）增加组胺（10μg/大鼠）诱导的打哈欠。在注射美吡拉敏加组胺之前注射西红花苷和藏红花醛也会引起打哈欠。

结论

本研究结果表明中枢组胺具有诱导打哈欠的作用，这一作用被美吡拉敏抑制。西红花苷和藏红花醛增加组胺诱导的打哈欠，并且在组胺作用被阻断时也会引起打哈欠。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e47b/4967840/782177d12fa0/AJP-6-442-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e47b/4967840/966691a30bea/AJP-6-442-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e47b/4967840/484c2c5aa2a8/AJP-6-442-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e47b/4967840/763cabbad464/AJP-6-442-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e47b/4967840/782177d12fa0/AJP-6-442-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e47b/4967840/966691a30bea/AJP-6-442-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e47b/4967840/484c2c5aa2a8/AJP-6-442-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e47b/4967840/763cabbad464/AJP-6-442-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e47b/4967840/782177d12fa0/AJP-6-442-g004.jpg

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