Rubin Jonathan M, Horowitz Jeffrey C, Sisson Thomas H, Kim Kang, Ortiz Luis A, Hamilton James D
University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan, Ann Arbor, Michigan, USA.
Ultrasound Med Biol. 2016 Nov;42(11):2525-2531. doi: 10.1016/j.ultrasmedbio.2016.05.020. Epub 2016 Aug 10.
Local lung function is difficult to evaluate, because most lung function estimates are either global in nature (e.g., pulmonary function tests) or require equipment that cannot be used at a patient's bedside, such as computed tomography. Yet, local function measurements would be highly desirable for many reasons. Recently, we were able to track displacements of the lung surface during breathing. We have now extended these results to measuring lung strains during respiration as a means of assessing local lung ventilation. We studied two human volunteers and 14 mice with either normal lung function or experimentally induced pulmonary fibrosis. The differences in strains between the control, normal mice and those with pulmonary fibrosis were significant (p < 0.0001), whereas the strains measured in the human volunteers closely matched linear strains predicted from the literature. It may be possible to use ultrasonography to assess local lung ventilation in a clinical setting.
局部肺功能难以评估，因为大多数肺功能评估本质上都是整体性的（例如肺功能测试），或者需要无法在患者床边使用的设备，如计算机断层扫描。然而，出于多种原因，局部功能测量非常必要。最近，我们能够追踪呼吸过程中肺表面的位移。我们现在将这些结果扩展到测量呼吸过程中的肺应变，作为评估局部肺通气的一种方法。我们研究了两名人类志愿者和14只肺功能正常或实验性诱导肺纤维化的小鼠。对照正常小鼠和肺纤维化小鼠之间的应变差异显著（p < 0.0001），而在人类志愿者中测量的应变与文献预测的线性应变密切匹配。在临床环境中使用超声检查评估局部肺通气可能是可行的。
