Beigh S A, Soodan J S, Bhat A M
Department of Clinical Veterinary Medicine, Ethics & Jurisprudence, Faculty of Veterinary Science and Animal Husbandry, Shere-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar Campus, Srinagar-191121, J&K, India.
Division of Teaching Veterinary Clinical Complex, Faculty of Veterinary Science and Animal Husbandry, Shere-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R.S. Pura 181102, Jammu, J&K, India.
Vet Parasitol. 2016 Aug 30;227:30-4. doi: 10.1016/j.vetpar.2016.07.013. Epub 2016 Jul 15.
The present study was aimed to determine the effect on liver, associated oxidative stress, trace element and vitamin alteration in dogs with sarcoptic mange. A total of 24 dogs with clinically established diagnosis of sarcoptic mange, divided into two groups, severely infested group (n=9) and mild/moderately infested group (n=15), according to the extent of skin lesions caused by sarcoptic mange and 6 dogs as control group were included in the present study. In comparison to healthy control hemoglobin, PCV, and TEC were significantly (P<0.05) decreased in dogs with sarcoptic mange however, significant increase in TLC along with neutrophilia and lymphopenia was observed only in severely infested dogs. The albumin, glucose and cholesterol were significantly (P<0.05) decreased and globulin, ALT, AST and bilirubin were significantly (P<0.05) increased in severely infested dogs when compared to other two groups. Malondialdehyde (MDA) levels were significantly (P<0.01) higher in dogs with sarcoptic mange, with levels highest in severely infested groups. Activity of superoxide dismutase (SOD) (P<0.05) and catalase were significantly (P<0.01) lower in sarcoptic infested dogs when compared with the healthy control group. Zinc and copper levels in dogs with sarcoptic mange were significantly (P<0.05) lower when compared with healthy control group with the levels lowest in severely infested group. Vitamin A and vitamin C levels were significantly (P<0.05) lower in sarcoptic infested dogs when compared to healthy control. From the present study, it was concluded that sarcoptic mange in dogs affects the liver and the infestation is associated with oxidant/anti-oxidant imbalance, significant alteration in trace elements and vitamins.
本研究旨在确定疥螨病犬肝脏的影响、相关氧化应激、微量元素和维生素的变化。本研究纳入了24只临床确诊为疥螨病的犬，根据疥螨病引起的皮肤病变程度分为两组，重度感染组（n = 9）和轻度/中度感染组（n = 15），并将6只犬作为对照组。与健康对照组相比，疥螨病犬的血红蛋白、红细胞压积和红细胞计数显著降低（P<0.05），然而，仅在重度感染犬中观察到白细胞总数显著增加以及中性粒细胞增多和淋巴细胞减少。与其他两组相比，重度感染犬的白蛋白、葡萄糖和胆固醇显著降低（P<0.05），球蛋白、谷丙转氨酶、谷草转氨酶和胆红素显著升高（P<0.05）。疥螨病犬的丙二醛（MDA）水平显著升高（P<0.01），重度感染组水平最高。与健康对照组相比，感染疥螨的犬超氧化物歧化酶（SOD）活性显著降低（P<0.05），过氧化氢酶活性显著降低（P<0.01）。与健康对照组相比，疥螨病犬的锌和铜水平显著降低（P<0.05），重度感染组水平最低。与健康对照组相比，感染疥螨的犬维生素A和维生素C水平显著降低（P<0.05）。从本研究得出结论，犬疥螨病会影响肝脏，感染与氧化/抗氧化失衡、微量元素和维生素的显著变化有关。
