Arlian L G, Morgan M S, Rapp C M, Vyszenski-Moher D L
Department of Biological Sciences, Wright State University, Dayton, Ohio 45435, USA.
J Parasitol. 1995 Oct;81(5):698-702.
Sequential changes in pathology were examined for scabies-infested dogs to determine the effects of infestation with Sarcoptes scabiei var. canis. During 8 wk of infestation with S. scabiei, the progression of the disease was evaluated weekly by skin scrape, clinical examination, and blood analyses. At 8 wk, selected organs were microscopically examined for histopathology. All infested dogs developed an advanced level of scabies infestation by 8 wk. Of the 36 blood parameters evaluated, only values for erythrocyte sedimentation rate (ESR) deviated significantly from the normal ranges for dogs. However, infested dogs had significantly (P < 0.01) lower average hemoglobin and hematocrit concentrations after 8 wk of infestation compared to their values prior to infestation or to the values for the control dogs. Red blood cell levels for infested dogs dropped significantly (P < 0.01) from preinfestation concentrations by week 8. Conversely, by 8 wk total white blood cell and neutrophil concentrations were significantly (P < 0.01) greater than uninfested controls. Also, whereas average eosinophil concentrations were not statistically different for infested dogs compared to controls, some individual infested dogs exhibited eosinophilia at 4-8 wk of infestation. The ESRs for infested dogs were significantly (P < 0.01) greater at week 6 and 8 than for experimental dogs prior to infestation or control dogs. All parameters except neutrophils had returned to preinfestation levels by 2 wk after treatment for scabies. Neutrophil concentrations were no longer significantly different by 4 wk posttreatment. There were no significant differences in serum enzyme, biochemical and electrolyte concentrations between infested and control dogs.(ABSTRACT TRUNCATED AT 250 WORDS)
研究了疥疮感染犬的病理变化顺序，以确定犬疥螨感染的影响。在感染犬疥螨的8周期间，每周通过皮肤刮片、临床检查和血液分析评估疾病进展。在第8周时，对选定器官进行显微镜组织病理学检查。所有感染犬在8周时都发展为重度疥疮感染。在评估的36项血液参数中，只有红细胞沉降率（ESR）的值与犬的正常范围有显著差异。然而，与感染前或对照犬的值相比，感染犬在感染8周后的平均血红蛋白和血细胞比容浓度显著降低（P<0.01）。到第8周，感染犬的红细胞水平比感染前浓度显著下降（P<0.01）。相反，到第8周时，总白细胞和中性粒细胞浓度显著高于未感染对照犬（P<0.01）。此外，虽然感染犬的平均嗜酸性粒细胞浓度与对照犬相比无统计学差异，但一些个体感染犬在感染4 - 8周时出现嗜酸性粒细胞增多。感染犬的ESR在第6周和第8周时显著高于感染前的实验犬或对照犬（P<0.01）。除中性粒细胞外，所有参数在治疗疥疮2周后均恢复到感染前水平。治疗后4周中性粒细胞浓度不再有显著差异。感染犬和对照犬之间的血清酶、生化和电解质浓度无显著差异。（摘要截短至250字）
