Nanomedicine Laboratory, Faculty of Medical and Human Sciences and National Graphene Institute, University of Manchester, Manchester, United Kingdom; Institute of Advanced Science and Industrial Technology (AIST), Tsukuba, Ibaraki, Japan.
Nanomedicine Laboratory, Faculty of Medical and Human Sciences and National Graphene Institute, University of Manchester, Manchester, United Kingdom.
Int J Nanomedicine. 2016 Jul 22;11:3317-30. doi: 10.2147/IJN.S103162. eCollection 2016.
In this work, we report that the biodistribution and excretion of carbon nanohorns (CNHs) in mice are dependent on their size and functionalization. Small-sized CNHs (30-50 nm; S-CNHs) and large-sized CNHs (80-100 nm; L-CNHs) were chemically functionalized and radiolabeled with [(111)In]-diethylenetriaminepentaacetic acid and intravenously injected into mice. Their tissue distribution profiles at different time points were determined by single photon emission computed tomography/computed tomography. The results showed that the S-CNHs circulated longer in blood, while the L-CNHs accumulated faster in major organs like the liver and spleen. Small amounts of S-CNHs- and L-CNHs were excreted in urine within the first few hours postinjection, followed by excretion of smaller quantities within the next 48 hours in both urine and feces. The kinetics of excretion for S-CNHs were more rapid than for L-CNHs. Both S-CNH and L-CNH material accumulated mainly in the liver and spleen; however, S-CNH accumulation in the spleen was more prominent than in the liver.
在这项工作中，我们报告说，碳纳米角（CNHs）在小鼠体内的分布和排泄取决于其尺寸和功能化。小尺寸的 CNHs（30-50nm；S-CNHs）和大尺寸的 CNHs（80-100nm；L-CNHs）经过化学功能化和放射性标记[(111)In]-二乙三胺五乙酸后，通过静脉注射到小鼠体内。通过单光子发射计算机断层扫描/计算机断层扫描来确定它们在不同时间点的组织分布情况。结果表明，S-CNHs 在血液中循环时间更长，而 L-CNHs 在肝脏和脾脏等主要器官中更快地积累。小部分的 S-CNHs 和 L-CNHs 在注射后的头几个小时内通过尿液排出，随后在接下来的 48 小时内通过尿液和粪便排出更少的量。S-CNH 的排泄动力学比 L-CNH 更快。S-CNH 和 L-CNH 材料主要积聚在肝脏和脾脏中；然而，S-CNH 在脾脏中的积聚比在肝脏中更为明显。
