Nanotube Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.
Adv Healthc Mater. 2014 Feb;3(2):239-44. doi: 10.1002/adhm.201300192. Epub 2013 Jul 5.
With the increase in the projected use of nanocarbons, such as carbon nanohorns (CNHs), carbon nanotubes (CNTs), and nanographenes, in medicine, the biodegradation and excretion of these materials has attracted increasing interest. Here, the excretion and pharmacokinetics of Gd2 O3 nanoparticle labels encapsulated within CNHs after their intravenous injection into mice is studied. The results show that CNHs quantitatively changed with the postinjection time in blood vessels, livers, and other organs. About 40% of the injected CNHs are lost from the mouse body at a postinjection time of 30 d; 15% are excreted in feces, most likely via the bililary pathway into the intestine, whereas the remaining 25% are inferred to be partly or completely degraded.
随着碳纳米角（CNHs）、碳纳米管（CNTs）和纳米石墨烯等纳米碳材料在医学中的预期应用增加，这些材料的生物降解和排泄引起了越来越多的关注。在这里，研究了静脉注射到小鼠体内的 Gd2 O3 纳米颗粒标记物被包裹在 CNHs 中的排泄和药代动力学。结果表明，CNHs 随注射后时间在血管、肝脏和其他器官中定量变化。在注射后 30 天，大约 40%的注射 CNHs 从老鼠体内丢失；15%通过胆汁途径排泄到粪便中，很可能进入肠道，而其余 25%则被推断为部分或完全降解。
